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PDB: 94 results

8E1A
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Structure-based study to overcome cross-reactivity of novel androgen receptor inhibitors
Descriptor: 1,2-ETHANEDIOL, 4-[4-(3-fluoro-2-methoxyphenyl)-1,3-thiazol-2-yl]morpholine, Androgen receptor
Authors:Lallous, N, Li, H, Radaeva, M, Dalal, K, Leblanc, E, Ban, F, Ciesielski, F, Chow, B, Morin, M, Singh, K, Rennie, P.S, Cherkasov, A.
Deposit date:2022-08-10
Release date:2022-09-14
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Structure-Based Study to Overcome Cross-Reactivity of Novel Androgen Receptor Inhibitors.
Cells, 11, 2022
7ZTZ
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Crystal structure of mutant AR-LBD (Y764C) bound to dihydrotestosterone
Descriptor: 5-ALPHA-DIHYDROTESTOSTERONE, Androgen receptor, IMIDAZOLE, ...
Authors:Alegre-Marti, A, Jimenez-Panizo, A, Estebanez-Perpina, E, Fuentes-Prior, P.
Deposit date:2022-05-11
Release date:2023-03-22
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:A hotspot for posttranslational modifications on the androgen receptor dimer interface drives pathology and anti-androgen resistance.
Sci Adv, 9, 2023
4OHA
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BU of 4oha by Molmil
Crystal structure of T877A-AR-LBD bound with co-regulator peptide
Descriptor: Androgen receptor, HYDROXYFLUTAMIDE, SULFATE ION, ...
Authors:Liu, J.S, Hsu, C.L, Wu, W.G.
Deposit date:2014-01-17
Release date:2014-08-20
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Identification of a new androgen receptor (AR) co-regulator BUD31 and related peptides to suppress wild-type and mutated AR-mediated prostate cancer growth via peptide screening and X-ray structure analysis.
Mol Oncol, 8, 2014
5V8Q
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BU of 5v8q by Molmil
Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs): Part III
Descriptor: 4-[(2S,3S)-2-ethyl-3-hydroxy-5-oxopyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile, Androgen receptor, GLYCEROL
Authors:Wilson, K.P.
Deposit date:2017-03-22
Release date:2017-05-24
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.44 Å)
Cite:Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs) Part III: Discovery of 4-(5-oxopyrrolidine-1-yl)benzonitrile derivative 2f as a clinical candidate.
Bioorg. Med. Chem., 25, 2017
2AX6
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Crystal Structure Of The Androgen Receptor Ligand Binding Domain T877A Mutant In Complex With Hydroxyflutamide
Descriptor: Androgen receptor, HYDROXYFLUTAMIDE
Authors:Bohl, C.E, Miller, D.D, Chen, J, Bell, C.E, Dalton, J.T.
Deposit date:2005-09-03
Release date:2005-09-20
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural Basis for Accommodation of Nonsteroidal Ligands in the Androgen Receptor
J.Biol.Chem., 280, 2005
3L3X
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BU of 3l3x by Molmil
Crystal structure of DHT-bound androgen receptor in complex with the first motif of steroid receptor coactivator 3
Descriptor: 5-ALPHA-DIHYDROTESTOSTERONE, Androgen receptor, Nuclear receptor coactivator 3
Authors:Zhou, X.E, Suino-Powell, K.M, Li, J, He, A, MacKeigan, J.P, Melcher, K, Yong, E.-L, Xu, H.E.
Deposit date:2009-12-18
Release date:2010-01-12
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Identification of SRC3/AIB1 as a Preferred Coactivator for Hormone-activated Androgen Receptor.
J.Biol.Chem., 285, 2010
8FH0
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BU of 8fh0 by Molmil
Crystal structure of mutant Androgen Receptor ligand binding domain H875Y/F877L/T878A with DHT
Descriptor: 5-ALPHA-DIHYDROTESTOSTERONE, Androgen receptor, SULFATE ION
Authors:Doamekpor, S.K, Tong, L.
Deposit date:2022-12-13
Release date:2023-04-12
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:A partially open conformation of an androgen receptor ligand-binding domain with drug-resistance mutations.
Acta Crystallogr.,Sect.F, 79, 2023
8FH2
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Crystal structure of mutant Androgen Receptor ligand binding domain L702H/H875Y with DHT
Descriptor: 5-ALPHA-DIHYDROTESTOSTERONE, Androgen receptor, SULFATE ION
Authors:Doamekpor, S.K, Tong, L.
Deposit date:2022-12-13
Release date:2023-04-12
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:A partially open conformation of an androgen receptor ligand-binding domain with drug-resistance mutations.
Acta Crystallogr.,Sect.F, 79, 2023
8FGZ
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BU of 8fgz by Molmil
Crystal structure of mutant Androgen Receptor ligand binding domain L702H/H875Y/F877L with DHT
Descriptor: 5-ALPHA-DIHYDROTESTOSTERONE, Androgen receptor, SULFATE ION
Authors:Doamekpor, S.K, Tong, L.
Deposit date:2022-12-13
Release date:2023-04-12
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:A partially open conformation of an androgen receptor ligand-binding domain with drug-resistance mutations.
Acta Crystallogr.,Sect.F, 79, 2023
2AM9
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Crystal structure of human androgen receptor ligand binding domain in complex with testosterone
Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Androgen receptor, GLYCEROL, ...
Authors:Pereira de Jesus-Tran, K, Cote, P.-L, Cantin, L, Blanchet, J, Labrie, F, Breton, R.
Deposit date:2005-08-09
Release date:2006-05-16
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Comparison of crystal structures of human androgen receptor ligand-binding domain complexed with various agonists reveals molecular determinants responsible for binding affinity.
Protein Sci., 15, 2006
2AX9
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Crystal Structure Of The Androgen Receptor Ligand Binding Domain In Complex With R-3
Descriptor: (R)-3-BROMO-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE, Androgen receptor
Authors:Bohl, C.E, Miller, D.D, Chen, J, Bell, C.E, Dalton, J.T.
Deposit date:2005-09-03
Release date:2005-09-20
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural Basis for Accommodation of Nonsteroidal Ligands in the Androgen Receptor
J.Biol.Chem., 280, 2005
3B66
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Crystal structure of the androgen receptor ligand binding domain in complex with SARM S-21
Descriptor: 4-{[(1R,2S)-1,2-dihydroxy-2-methyl-3-(4-nitrophenoxy)propyl]amino}-2-(trifluoromethyl)benzonitrile, Androgen receptor
Authors:Bohl, C.E, Miller, D.D, Dalton, J.T.
Deposit date:2007-10-27
Release date:2008-09-09
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Effect of B-ring substitution pattern on binding mode of propionamide selective androgen receptor modulators
Bioorg.Med.Chem.Lett., 18, 2008
2PNU
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Crystal structure of human androgen receptor ligand-binding domain in complex with EM-5744
Descriptor: (5S,8R,9S,10S,13R,14S,17S)-13-{2-[(3,5-DIFLUOROBENZYL)OXY]ETHYL}-17-HYDROXY-10-METHYLHEXADECAHYDRO-3H-CYCLOPENTA[A]PHENANTHREN-3-ONE, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ...
Authors:Cantin, L, Faucher, F, Couture, J.F, Pereira de Jesus-Tran, K, Legrand, P, Ciobanu, C.L, Singh, S.M, Labrie, F, Breton, R.
Deposit date:2007-04-25
Release date:2007-09-11
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural Characterization of the Human Androgen Receptor Ligand-binding Domain Complexed with EM5744, a Rationally Designed Steroidal Ligand Bearing a Bulky Chain Directed toward Helix 12.
J.Biol.Chem., 282, 2007
1T65
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BU of 1t65 by Molmil
Crystal structure of the androgen receptor ligand binding domain with DHT and a peptide derived form its physiological coactivator GRIP1 NR box 2 bound in a non-helical conformation
Descriptor: 5-ALPHA-DIHYDROTESTOSTERONE, Androgen receptor, Nuclear receptor coactivator 2
Authors:Estebanez-Perpina, E, Moore, J.M.R, Mar, E, Nguyen, P, Delgado-Rodrigues, E, Baxter, J.D, Webb, P, Fletterick, R.J, Guy, R.K.
Deposit date:2004-05-05
Release date:2005-01-25
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:The Molecular Mechanisms of Coactivator Utilization in Ligand-dependent Transactivation by the Androgen Receptor.
J.Biol.Chem., 280, 2005
7ZU1
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BU of 7zu1 by Molmil
Crystal structure of mutant AR-LBD (V758A) bound to dihydrotestosterone
Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 5-ALPHA-DIHYDROTESTOSTERONE, Androgen receptor, ...
Authors:Alegre-Marti, A, Jimenez-Panizo, A, Estebanez-Perpina, E, Fuentes-Prior, P.
Deposit date:2022-05-11
Release date:2023-03-22
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:A hotspot for posttranslational modifications on the androgen receptor dimer interface drives pathology and anti-androgen resistance.
Sci Adv, 9, 2023
8FH1
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BU of 8fh1 by Molmil
Crystal structure of mutant Androgen Receptor ligand binding domain F877L/T878A with DHT
Descriptor: 5-ALPHA-DIHYDROTESTOSTERONE, Androgen receptor, SULFATE ION
Authors:Doamekpor, S.K, Tong, L.
Deposit date:2022-12-13
Release date:2023-04-12
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:A partially open conformation of an androgen receptor ligand-binding domain with drug-resistance mutations.
Acta Crystallogr.,Sect.F, 79, 2023
3V49
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BU of 3v49 by Molmil
Structure of ar lbd with activator peptide and sarm inhibitor 1
Descriptor: 4-[(4R)-4-(4-hydroxyphenyl)-3,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile, Androgen receptor, activator peptide, ...
Authors:Nique, F, Hebbe, S, Peixoto, C, Annoot, D, Lefrancois, J.-M, Duval, E, Michoux, L, Triballeau, N, Lemoullec, J.-M, Mollat, P, Thauvin, M, Prange, T, Minet, D, Clement-Lacroix, P, Robin-Jagerschmidt, C, Fleury, D, Guedin, D, Deprez, P.
Deposit date:2011-12-14
Release date:2012-09-05
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Discovery of diarylhydantoins as new selective androgen receptor modulators.
J.Med.Chem., 55, 2012
2AX8
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BU of 2ax8 by Molmil
Crystal Structure Of The Androgen Receptor Ligand Binding Domain W741L Mutant In Complex With S-1
Descriptor: Androgen receptor, S-3-(4-FLUOROPHENOXY)-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE
Authors:Bohl, C.E, Miller, D.D, Chen, J, Bell, C.E, Dalton, J.T.
Deposit date:2005-09-03
Release date:2005-09-20
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural Basis for Accommodation of Nonsteroidal Ligands in the Androgen Receptor
J.Biol.Chem., 280, 2005
3RLL
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BU of 3rll by Molmil
Crystal structure of the T877A androgen receptor ligand binding domain in complex with (S)-N-(4-Cyano-3-(trifluoromethyl)phenyl)-3-(4-cyanonaphthalen-1-yloxy)-2-hydroxy-2-methylpropanamide
Descriptor: (2S)-3-[(4-cyanonaphthalen-1-yl)oxy]-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide, Androgen receptor
Authors:Bohl, C.E, Duke, C.B, Jones, A, Dalton, J.T, Miller, D.D.
Deposit date:2011-04-19
Release date:2011-05-04
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Unexpected binding orientation of bulky-B-ring anti-androgens and implications for future drug targets.
J.Med.Chem., 54, 2011
7ZU2
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BU of 7zu2 by Molmil
Crystal structure of mutant AR-LBD (Q799E) bound to dihydrotestosterone
Descriptor: 5-ALPHA-DIHYDROTESTOSTERONE, Androgen receptor, IMIDAZOLE
Authors:Alegre-Marti, A, Jimenez-Panizo, A, Estebanez-Perpina, E, Fuentes-Prior, P.
Deposit date:2022-05-11
Release date:2023-03-22
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:A hotspot for posttranslational modifications on the androgen receptor dimer interface drives pathology and anti-androgen resistance.
Sci Adv, 9, 2023
2AMB
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BU of 2amb by Molmil
Crystal structure of human androgen receptor ligand binding domain in complex with tetrahydrogestrinone
Descriptor: 17-HYDROXY-18A-HOMO-19-NOR-17ALPHA-PREGNA-4,9,11-TRIEN-3-ONE, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Pereira de Jesus-Tran, K, Cote, P.-L, Cantin, L, Blanchet, J, Labrie, F, Breton, R.
Deposit date:2005-08-09
Release date:2006-05-16
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Comparison of crystal structures of human androgen receptor ligand-binding domain complexed with various agonists reveals molecular determinants responsible for binding affinity.
Protein Sci., 15, 2006
2PIT
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BU of 2pit by Molmil
Androgen receptor LBD with small molecule
Descriptor: 5-ALPHA-DIHYDROTESTOSTERONE, Androgen receptor, SULFATE ION, ...
Authors:Estebanez-Perpina, E, Arnold, A.A, Baxter, J.D, Webb, P, Guy, R.K, Fletterick, K.R.
Deposit date:2007-04-13
Release date:2007-09-25
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:A surface on the androgen receptor that allosterically regulates coactivator binding.
Proc.Natl.Acad.Sci.Usa, 104, 2007
1Z95
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BU of 1z95 by Molmil
Crystal Structure of the Androgen Receptor Ligand-binding Domain W741L Mutant Complex with R-bicalutamide
Descriptor: Androgen Receptor, R-BICALUTAMIDE, SULFATE ION
Authors:Bohl, C.E, Gao, W, Miller, D.D, Bell, C.E, Dalton, J.T.
Deposit date:2005-03-31
Release date:2005-04-19
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis for antagonism and resistance of bicalutamide in prostate cancer.
Proc.Natl.Acad.Sci.Usa, 102, 2005
4OEZ
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BU of 4oez by Molmil
Crystal structure of AR-LBD bound with co-regulator peptide
Descriptor: 5-ALPHA-DIHYDROTESTOSTERONE, Androgen receptor, SULFATE ION, ...
Authors:Liu, J.S, Hsu, C.L, Wu, W.G.
Deposit date:2014-01-14
Release date:2014-08-20
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Identification of a new androgen receptor (AR) co-regulator BUD31 and related peptides to suppress wild-type and mutated AR-mediated prostate cancer growth via peptide screening and X-ray structure analysis.
Mol Oncol, 8, 2014
2OZ7
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BU of 2oz7 by Molmil
Crystal structure of the human androgen receptor T877A mutant ligand-binding domain with cyproterone acetate
Descriptor: Androgen receptor, CYPROTERONE ACETATE
Authors:Bohl, C.E, Wu, Z, Miller, D.D, Bell, C.E, Dalton, J.T.
Deposit date:2007-02-25
Release date:2007-03-27
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of the T877A human androgen receptor ligand-binding domain complexed to cyproterone acetate provides insight for ligand-induced conformational changes and structure-based drug design.
J.Biol.Chem., 282, 2007

 

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