3RLL

Crystal structure of the T877A androgen receptor ligand binding domain in complex with (S)-N-(4-Cyano-3-(trifluoromethyl)phenyl)-3-(4-cyanonaphthalen-1-yloxy)-2-hydroxy-2-methylpropanamide

Summary for 3RLL

Entry DOI	10.2210/pdb3rll/pdb
Related	3RLJ
Descriptor	Androgen receptor, (2S)-3-[(4-cyanonaphthalen-1-yl)oxy]-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide (3 entities in total)
Functional Keywords	steroid receptor, dht, testosterone, transcription
Biological source	Homo sapiens (human)
Cellular location	Nucleus: P10275
Total number of polymer chains	1
Total formula weight	29226.21
Authors	Bohl, C.E.,Duke, C.B.,Jones, A.,Dalton, J.T.,Miller, D.D. (deposition date: 2011-04-19, release date: 2011-05-04, Last modification date: 2023-09-13)
Primary citation	Duke, C.B.,Jones, A.,Bohl, C.E.,Dalton, J.T.,Miller, D.D. Unexpected binding orientation of bulky-B-ring anti-androgens and implications for future drug targets. J.Med.Chem., 54:3973-3976, 2011 Cited by PubMed: 21506597 DOI: 10.1021/jm2000097 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation