3RLL
Crystal structure of the T877A androgen receptor ligand binding domain in complex with (S)-N-(4-Cyano-3-(trifluoromethyl)phenyl)-3-(4-cyanonaphthalen-1-yloxy)-2-hydroxy-2-methylpropanamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Androgen receptor | polymer | 247 | 28786.8 | 1 | UniProt (P10275) Pfam (PF00104) In PDB | Homo sapiens (human) | Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4 |
| 2 | A | (2S)-3-[(4-cyanonaphthalen-1-yl)oxy]-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide | non-polymer | 439.4 | 1 | Chemie (RLL) | |||
| 3 | water | water | 18.0 | 98 | Chemie (HOH) |
Sequence modifications
A: 671 - 917 (UniProt: P10275)
| PDB | External Database | Details |
|---|---|---|
| Ala 877 | Thr 877 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 28786.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 439.4 | |
| All* | Total formula weight | 29226.2 |
