2AMB

Crystal structure of human androgen receptor ligand binding domain in complex with tetrahydrogestrinone

Summary for 2AMB

Related2AM9 2AMA
DescriptorAndrogen receptor, SULFATE ION, 17-HYDROXY-18A-HOMO-19-NOR-17ALPHA-PREGNA-4,9,11-TRIEN-3-ONE, ... (7 entities in total)
Functional Keywordsnuclear receptor, androgen receptor, ligand binding domain, thg, agonist, designer androgen, hormone-growth factor receptor complex, hormone/growth factor receptor
Biological sourceHomo sapiens (human)
Cellular locationNucleus P10275
Total number of polymer chains1
Total molecular weight31889.35
Authors
Pereira de Jesus-Tran, K.,Cote, P.-L.,Cantin, L.,Blanchet, J.,Labrie, F.,Breton, R. (deposition date: 2005-08-09, release date: 2006-05-16, Last modification date: 2011-07-13)
Primary citation
Pereira de Jesus-Tran, K.,Cote, P.-L.,Cantin, L.,Blanchet, J.,Labrie, F.,Breton, R.
Comparison of crystal structures of human androgen receptor ligand-binding domain complexed with various agonists reveals molecular determinants responsible for binding affinity.
Protein Sci., 15:987-999, 2006
PubMed: 16641486 (PDB entries with the same primary citation)
DOI: 10.1110/ps.051905906
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.75 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.223140.8%2.7%6.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report