1T65
Crystal structure of the androgen receptor ligand binding domain with DHT and a peptide derived form its physiological coactivator GRIP1 NR box 2 bound in a non-helical conformation
Summary for 1T65
Entry DOI | 10.2210/pdb1t65/pdb |
Related | 1T5Z 1T63 |
Descriptor | Androgen receptor, Nuclear receptor coactivator 2, 5-ALPHA-DIHYDROTESTOSTERONE, ... (4 entities in total) |
Functional Keywords | androgen receptor ligand binding domain grip1 nr box2 coactivators crystal structure non-helical, hormone-growth factor complex, hormone/growth factor |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus : P10275 Q15596 |
Total number of polymer chains | 2 |
Total formula weight | 31147.65 |
Authors | Estebanez-Perpina, E.,Moore, J.M.R.,Mar, E.,Nguyen, P.,Delgado-Rodrigues, E.,Baxter, J.D.,Webb, P.,Fletterick, R.J.,Guy, R.K. (deposition date: 2004-05-05, release date: 2005-01-25, Last modification date: 2024-02-14) |
Primary citation | Estebanez-Perpina, E.,Moore, J.M.R.,Mar, E.,Delgado-Rodrigues, E.,Nguyen, P.,Baxter, J.D.,Buehrer, B.M.,Webb, P.,Fletterick, R.J.,Guy, R.K. The Molecular Mechanisms of Coactivator Utilization in Ligand-dependent Transactivation by the Androgen Receptor. J.Biol.Chem., 280:8060-8068, 2005 Cited by PubMed: 15563469DOI: 10.1074/jbc.M407046200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.66 Å) |
Structure validation
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