1Z95
Crystal Structure of the Androgen Receptor Ligand-binding Domain W741L Mutant Complex with R-bicalutamide
Summary for 1Z95
Entry DOI | 10.2210/pdb1z95/pdb |
Descriptor | Androgen Receptor, SULFATE ION, R-BICALUTAMIDE, ... (4 entities in total) |
Functional Keywords | steroid hormones; receptors; cellular proliferation; cellular differentiation, transcription regulation, receptor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P10275 |
Total number of polymer chains | 1 |
Total formula weight | 29173.11 |
Authors | Bohl, C.E.,Gao, W.,Miller, D.D.,Bell, C.E.,Dalton, J.T. (deposition date: 2005-03-31, release date: 2005-04-19, Last modification date: 2023-08-23) |
Primary citation | Bohl, C.E.,Gao, W.,Miller, D.D.,Bell, C.E.,Dalton, J.T. Structural basis for antagonism and resistance of bicalutamide in prostate cancer. Proc.Natl.Acad.Sci.Usa, 102:6201-6206, 2005 Cited by PubMed: 15833816DOI: 10.1073/pnas.0500381102 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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