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3B5R

Crystal structure of the androgen receptor ligand binding domain in complex with SARM C-31

Summary for 3B5R
Entry DOI10.2210/pdb3b5r/pdb
Related2axa 3B65 3B66 3B67 3B68
DescriptorAndrogen receptor, (2S)-3-(4-chloro-3-fluorophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide (3 entities in total)
Functional Keywordsandrogen receptor, nonsteroidal, sarm, disease mutation, dna-binding, lipid-binding, metal-binding, nucleus, polymorphism, steroid-binding, transcription, transcription regulation, triplet repeat expansion, ubl conjugation, zinc, zinc-finger
Biological sourceHomo sapiens (Human)
Cellular locationNucleus: P10275
Total number of polymer chains1
Total formula weight29462.83
Authors
Bohl, C.E.,Miller, D.D.,Dalton, J.T. (deposition date: 2007-10-26, release date: 2008-09-09, Last modification date: 2024-02-21)
Primary citationBohl, C.E.,Wu, Z.,Chen, J.,Mohler, M.L.,Yang, J.,Hwang, D.J.,Mustafa, S.,Miller, D.D.,Bell, C.E.,Dalton, J.T.
Effect of B-ring substitution pattern on binding mode of propionamide selective androgen receptor modulators
Bioorg.Med.Chem.Lett., 18:5567-5570, 2008
Cited by
PubMed: 18805694
DOI: 10.1016/j.bmcl.2008.09.002
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

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