7ZU1

Crystal structure of mutant AR-LBD (V758A) bound to dihydrotestosterone

Summary for 7ZU1

Entry DOI	10.2210/pdb7zu1/pdb
Related	7ZTV 7ZTX 7ZTZ
Descriptor	Androgen receptor, 5-ALPHA-DIHYDROTESTOSTERONE, GLYCEROL, ... (8 entities in total)
Functional Keywords	hormone receptor, nuclear receptor, dht receptor, dna binding protein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	29726.89
Authors	Alegre-Marti, A.,Jimenez-Panizo, A.,Estebanez-Perpina, E.,Fuentes-Prior, P. (deposition date: 2022-05-11, release date: 2023-03-22, Last modification date: 2024-02-07)
Primary citation	Alegre-Marti, A.,Jimenez-Panizo, A.,Martinez-Tebar, A.,Poulard, C.,Peralta-Moreno, M.N.,Abella, M.,Anton, R.,Chinas, M.,Eckhard, U.,Piulats, J.M.,Rojas, A.M.,Fernandez-Recio, J.,Rubio-Martinez, J.,Le Romancer, M.,Aytes, A.,Fuentes-Prior, P.,Estebanez-Perpina, E. A hotspot for posttranslational modifications on the androgen receptor dimer interface drives pathology and anti-androgen resistance. Sci Adv, 9:eade2175-eade2175, 2023 Cited by PubMed: 36921044 DOI: 10.1126/sciadv.ade2175 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.68 Å)

Structure validation