PDB: 1628 resultsInfo pagesStatus searchChemie searchBIRD

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8YUV	Cryo-EM structure of the immepip-bound H3R-Gi complex Descriptor: 4-(1H-imidazol-5-ylmethyl)piperidine, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... Authors: Shen, Q, Tang, X, Wen, X, Cheng, S, Xiao, P, Zang, S, Shen, D, Jiang, L, Zheng, Y, Zhang, H, Xu, H, Mao, C, Zhang, M, Hu, W, Sun, J, Chen, Z, Zhang, Y. Deposit date: 2024-03-27 Release date: 2024-06-05 Last modified: 2024-07-03 Method: ELECTRON MICROSCOPY (3 Å) Cite: Molecular Determinant Underlying Selective Coupling of Primary G-Protein by Class A GPCRs. Adv Sci, 11, 2024
7T6B	Structure of S1PR2-heterotrimeric G13 signaling complex Descriptor: (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... Authors: Li, X, Chen, H. Deposit date: 2021-12-13 Release date: 2022-04-06 Last modified: 2022-06-29 Method: ELECTRON MICROSCOPY (3.19 Å) Cite: Structure of S1PR2-heterotrimeric G 13 signaling complex. Sci Adv, 8, 2022
8JT6	5-HT1A-Gi in complex with compound (R)-IHCH-7179 Descriptor: 1-(4-fluorophenyl)-4-[(7R)-2,5,11-triazatetracyclo[7.6.1.0^2,7.0^12,16]hexadeca-1(15),9,12(16),13-tetraen-5-yl]butan-1-one, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... Authors: Chen, Z, Xu, P, Huang, S, Xu, H.E, Wang, S. Deposit date: 2023-06-21 Release date: 2024-02-28 Last modified: 2024-05-08 Method: ELECTRON MICROSCOPY (3 Å) Cite: Flexible scaffold-based cheminformatics approach for polypharmacological drug design. Cell, 187, 2024
1B45	ALPHA-CNIA CONOTOXIN FROM CONUS CONSORS, NMR, 43 STRUCTURES Descriptor: ALPHA-CNIA Authors: Favreau, P, Krimm, I, Le Gall, F, Bobenrieth, M.J, Lamthanh, H, Bouet, F, Servent, D, Molgo, J, Menez, A, Letourneux, Y, Lancelin, J.M. Deposit date: 1999-01-05 Release date: 1999-07-09 Last modified: 2022-02-16 Method: SOLUTION NMR Cite: Biochemical characterization and nuclear magnetic resonance structure of novel alpha-conotoxins isolated from the venom of Conus consors. Biochemistry, 38, 1999
8SAI	Cryo-EM structure of GPR34-Gi complex Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... Authors: Yong, X.H, Zhao, C, Yan, W, Shao, Z.H. Deposit date: 2023-04-01 Release date: 2023-10-04 Method: ELECTRON MICROSCOPY (3.27 Å) Cite: Cryo-EM structures of human GPR34 enable the identification of selective antagonists. Proc.Natl.Acad.Sci.USA, 120, 2023
7EPT	Structural basis for the tethered peptide activation of adhesion GPCRs Descriptor: Adhesion G-protein coupled receptor D1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... Authors: Ping, Y.-Q, Xiao, P, Yang, F, Zhao, R.-J, Guo, S.-C, Yan, X, Wu, X, Liebscher, I, Xu, H.E, Sun, J.-P. Deposit date: 2021-04-27 Release date: 2022-05-11 Method: ELECTRON MICROSCOPY (3 Å) Cite: Structural basis for the tethered peptide activation of adhesion GPCRs. Nature, 604, 2022
8SMV	GPR161 Gs heterotrimer Descriptor: CHOLESTEROL, G-protein coupled receptor 161, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... Authors: Hoppe, N, Manglik, A, Harrison, S. Deposit date: 2023-04-26 Release date: 2024-02-21 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (2.74 Å) Cite: GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway. Biorxiv, 2023
7SR8	Molecular mechanism of the the wake-promoting agent TAK-925 Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Hypocretin receptor type 2, ... Authors: Yin, J, Chapman, K, Lian, P, De Brabander, J.K, Rosenbaum, D.M. Deposit date: 2021-11-08 Release date: 2022-06-08 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Molecular mechanism of the wake-promoting agent TAK-925. Nat Commun, 13, 2022
1TXB	SOLUTION NMR STRUCTURE OF TOXIN B, A LONG NEUROTOXIN FROM THE VENOM OF THE KING COBRA, 10 STRUCTURES Descriptor: TOXIN B Authors: Peng, S.-S, Kumar, T.K.S, Jayaraman, G, Chang, C.-C, Yu, C. Deposit date: 1996-07-20 Release date: 1997-10-15 Last modified: 2017-11-29 Method: SOLUTION NMR Cite: Solution structure of toxin b, a long neurotoxin from the venom of the king cobra (Ophiophagus hannah). J.Biol.Chem., 272, 1997
1TXA	SOLUTION NMR STRUCTURE OF TOXIN B, A LONG NEUROTOXIN FROM THE VENOM OF THE KING COBRA, MINIMIZED AVERAGE STRUCTURE Descriptor: TOXIN B Authors: Peng, S.-S, Kumar, T.K.S, Jayaraman, G, Chang, C.-C, Yu, C. Deposit date: 1996-07-20 Release date: 1997-10-15 Last modified: 2017-11-29 Method: SOLUTION NMR Cite: Solution structure of toxin b, a long neurotoxin from the venom of the king cobra (Ophiophagus hannah). J.Biol.Chem., 272, 1997
1XGB	ALPHA CONOTOXIN GI: 2-13;3-7 DISULFIDE BOND ISOMER NMR, 24 STRUCTURES Descriptor: ALPHA-CONOTOXIN GI Authors: Gehrmann, J, Alewood, P.F, Craik, D.J. Deposit date: 1998-01-18 Release date: 1999-02-16 Last modified: 2022-03-02 Method: SOLUTION NMR Cite: Structure determination of the three disulfide bond isomers of alpha-conotoxin GI: a model for the role of disulfide bonds in structural stability. J.Mol.Biol., 278, 1998
1XGA	ALPHA CONOTOXIN GI: 2-7;3-13 (NATIVE) DISULFIDE BOND ISOMER, NMR, 35 STRUCTURES Descriptor: ALPHA-CONOTOXIN GI Authors: Gehrmann, J, Alewood, P.F, Craik, D.J. Deposit date: 1998-01-18 Release date: 1999-02-16 Last modified: 2024-06-05 Method: SOLUTION NMR Cite: Structure determination of the three disulfide bond isomers of alpha-conotoxin GI: a model for the role of disulfide bonds in structural stability. J.Mol.Biol., 278, 1998
7EGR	Co-crystal structure of Ac-AChBPP in complex with RgIA Descriptor: MAGNESIUM ION, RgIA, Soluble acetylcholine receptor Authors: Wang, X.Q, Pan, S, Fan, Y.X, Xue, Y, Zhu, X.P, Luo, S.L. Deposit date: 2021-03-26 Release date: 2022-04-06 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.503 Å) Cite: Co-crystal structure of Ac-AChBPP in complex with RgIA To Be Published
6OTA	THREE-DIMENSIONAL STRUCTURE IN SOLUTION OF THE RIBBON DISULFIDE ISOMER OF THE NICOTINIC ACETYLCHOLINE RECEPTOR ANTAGONIST ALPHA-CONOTOXIN TxIA Descriptor: Alpha-conotoxin TxIA Authors: Clark, R.J, Nicke, A. Deposit date: 2019-05-02 Release date: 2020-05-06 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Structural and functional analysis of E. Coli-expressed 4/7 alpha-conotoxin analogues reveals preferential formation of ribbon isomers To Be Published
1LSI	LSIII (NMR, 23 STRUCTURES) Descriptor: LSIII Authors: Connolly, P.J, Stern, A.S, Hoch, J.C. Deposit date: 1995-11-26 Release date: 1996-03-15 Last modified: 2022-02-23 Method: SOLUTION NMR Cite: Solution structure of LSIII, a long neurotoxin from the venom of Laticauda semifasciata. Biochemistry, 35, 1996
7EW4	Cryo-EM structure of CYM-5541-bound Sphingosine 1-phosphate receptor 3 in complex with Gi protein Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... Authors: Zhao, C, Wang, W, Wang, H.L, Shao, Z.H. Deposit date: 2021-05-24 Release date: 2021-09-29 Last modified: 2022-02-16 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Structural insights into sphingosine-1-phosphate recognition and ligand selectivity of S1PR3-Gi signaling complexes. Cell Res., 32, 2022
7EW2	Cryo-EM structure of pFTY720-bound Sphingosine 1-phosphate receptor 3 in complex with Gi protein Descriptor: (2~{S})-2-azanyl-4-(4-octylphenyl)-2-[[oxidanyl-bis(oxidanylidene)-$l^{6}-phosphanyl]oxymethyl]butan-1-ol, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... Authors: Zhao, C, Wang, W, Wang, H.L, Shao, Z.H. Deposit date: 2021-05-24 Release date: 2021-09-29 Last modified: 2022-02-16 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Structural insights into sphingosine-1-phosphate recognition and ligand selectivity of S1PR3-Gi signaling complexes. Cell Res., 32, 2022
7EW3	Cryo-EM structure of S1P-bound Sphingosine 1-phosphate receptor 3 in complex with Gi protein Descriptor: (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... Authors: Zhao, C, Wang, W, Wang, H.L, Shao, Z.H. Deposit date: 2021-05-24 Release date: 2021-09-29 Last modified: 2022-02-16 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Structural insights into sphingosine-1-phosphate recognition and ligand selectivity of S1PR3-Gi signaling complexes. Cell Res., 32, 2022
5CO5	Crystal structure of Ac-AChBP in complex with conotoxin GIC Descriptor: Alpha-conotoxin GIC, Soluble acetylcholine receptor Authors: Wang, X.Q, Xu, M.Y, Luo, S.L, Lin, B. Deposit date: 2015-07-19 Release date: 2016-07-20 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crystal structure of Ac-AChBP in complex with conotoxin GIC To Be Published
1A0M	1.1 ANGSTROM CRYSTAL STRUCTURE OF A-CONOTOXIN [TYR15]-EPI Descriptor: ALPHA-CONOTOXIN [TYR15]-EPI Authors: Hu, S.-H, Loughnan, M, Miller, R, Weeks, C.M, Blessing, R.H, Alewood, P.F, Lewis, R.J, Martin, J.L. Deposit date: 1997-12-03 Release date: 1999-01-13 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.1 Å) Cite: The 1.1 A resolution crystal structure of [Tyr15]EpI, a novel alpha-conotoxin from Conus episcopatus, solved by direct methods. Biochemistry, 37, 1998
8KGK	Cryo-EM structure of the GPR61-Gs complex Descriptor: G-protein coupled receptor 61, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... Authors: Nie, Y, Qiu, Z, Zheng, S. Deposit date: 2023-08-19 Release date: 2023-10-11 Method: ELECTRON MICROSCOPY (3.16 Å) Cite: Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive G s signaling. Nat Commun, 14, 2023
8G94	Structure of CD69-bound S1PR1 coupled to heterotrimeric Gi Descriptor: Early activation antigen CD69, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... Authors: Chen, H, Li, X. Deposit date: 2023-02-21 Release date: 2023-04-19 Last modified: 2023-04-26 Method: ELECTRON MICROSCOPY (3.15 Å) Cite: Transmembrane protein CD69 acts as an S1PR1 agonist. Elife, 12, 2023
8DDW	cryo-EM structure of TRPM3 ion channel in complex with Gbg, tethered by ALFA-nanobody Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Transient receptor potential cation channel, ... Authors: Zhao, C, MacKinnon, R. Deposit date: 2022-06-19 Release date: 2022-11-02 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (4.7 Å) Cite: Structural and functional analyses of a GPCR-inhibited ion channel TRPM3. Neuron, 111, 2023
8DDX	cryo-EM structure of TRPM3 ion channel in complex with Gbg in the presence of PIP2, tethered by ALFA-nanobody Descriptor: (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... Authors: Zhao, C, MacKinnon, R. Deposit date: 2022-06-19 Release date: 2022-11-02 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Structural and functional analyses of a GPCR-inhibited ion channel TRPM3. Neuron, 111, 2023
1MTQ	THREE-DIMENSIONAL SOLUTION STRUCTURE OF ALPHA-CONOTOXIN GID BY NMR SPECTROSCOPY Descriptor: alpha-conotoxin GID Authors: Nicke, A, Loughnan, M.L, Millard, E.L, Alewood, P.F, Adams, D.J, Daly, N.L, Craik, D.J, Lewis, R.J. Deposit date: 2002-09-22 Release date: 2003-02-11 Last modified: 2020-06-24 Method: SOLUTION NMR Cite: Isolation, Structure, and Activity of GID, a Novel alpha 4/7-Conotoxin with an Extended N-terminal Sequence J.BIOL.CHEM., 278, 2003

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