7EW4
Cryo-EM structure of CYM-5541-bound Sphingosine 1-phosphate receptor 3 in complex with Gi protein
Summary for 7EW4
Entry DOI | 10.2210/pdb7ew4/pdb |
EMDB information | 31347 |
Descriptor | Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total) |
Functional Keywords | complex, agonist, membrane protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 5 |
Total formula weight | 163319.98 |
Authors | Zhao, C.,Wang, W.,Wang, H.L.,Shao, Z.H. (deposition date: 2021-05-24, release date: 2021-09-29, Last modification date: 2022-02-16) |
Primary citation | Zhao, C.,Cheng, L.,Wang, W.,Wang, H.,Luo, Y.,Feng, Y.,Wang, X.,Fu, H.,Cai, Y.,Yang, S.,Fu, P.,Yan, W.,Shao, Z. Structural insights into sphingosine-1-phosphate recognition and ligand selectivity of S1PR3-Gi signaling complexes. Cell Res., 32:218-221, 2022 Cited by PubMed: 34545189DOI: 10.1038/s41422-021-00567-w PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.2 Å) |
Structure validation
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