7EPT

Structural basis for the tethered peptide activation of adhesion GPCRs

Summary for 7EPT

Entry DOI	10.2210/pdb7ept/pdb
EMDB information	31232
Descriptor	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
Functional Keywords	adhesion gpcr, gpr133, structural protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	5
Total formula weight	138316.35
Authors	Ping, Y.-Q.,Xiao, P.,Yang, F.,Zhao, R.-J.,Guo, S.-C.,Yan, X.,Wu, X.,Liebscher, I.,Xu, H.E.,Sun, J.-P. (deposition date: 2021-04-27, release date: 2022-05-11)
Primary citation	Ping, Y.Q.,Xiao, P.,Yang, F.,Zhao, R.J.,Guo, S.C.,Yan, X.,Wu, X.,Zhang, C.,Lu, Y.,Zhao, F.,Zhou, F.,Xi, Y.T.,Yin, W.,Liu, F.Z.,He, D.F.,Zhang, D.L.,Zhu, Z.L.,Jiang, Y.,Du, L.,Feng, S.Q.,Schoneberg, T.,Liebscher, I.,Xu, H.E.,Sun, J.P. Structural basis for the tethered peptide activation of adhesion GPCRs. Nature, 604:763-770, 2022 Cited by PubMed: 35418678 DOI: 10.1038/s41586-022-04619-y PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3 Å)

Structure validation