7EPT
Structural basis for the tethered peptide activation of adhesion GPCRs
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 394 | 45727.4 | 1 | Pfam (PF00503) UniProt (by SIFTS) (P63092) In PDB | Homo sapiens (Human) | |
2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 358 | 39489.2 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (human) | Transducin beta chain 1 |
3 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (human) | G gamma-I |
4 | N | Nanobody-35 | polymer | 128 | 13885.4 | 1 | synthetic construct | ||
5 | R | Adhesion G-protein coupled receptor D1 | polymer | 283 | 31096.7 | 1 | UniProt (Q6QNK2) Pfam (PF00002) In PDB | Homo sapiens (human) | G-protein coupled receptor 133,G-protein coupled receptor PGR25 |
6 | R | PALMITIC ACID | non-polymer | 256.4 | 1 | Chemie (PLM) |
Sequence modifications
B: 2 - 340 (UniProt: P62873)
PDB | External Database | Details |
---|---|---|
Met -17 | - | initiating methionine |
His -16 | - | expression tag |
His -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
Leu -10 | - | expression tag |
Glu -9 | - | expression tag |
Val -8 | - | expression tag |
Leu -7 | - | expression tag |
Phe -6 | - | expression tag |
Gln -5 | - | expression tag |
Gly -4 | - | expression tag |
Pro -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
Ser 0 | - | expression tag |
Gln 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 138059.9 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 256.4 | |
All* | Total formula weight | 138316.4 |