8DDX

cryo-EM structure of TRPM3 ion channel in complex with Gbg in the presence of PIP2, tethered by ALFA-nanobody

Summary for 8DDX

• Entry DOI: 10.2210/pdb8ddx/pdb
• Related: 8DDQ 8DDR 8DDS 8DDT 8DDU 8DDV 8DDW
• EMDB information: 27345
• Descriptor: Transient receptor potential cation channel, subfamily M, member 3, Unidentified segment at the N-terminus of TRPM3, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (8 entities in total)
• Functional Keywords: trpm3, ion channel, gbg, pip2, membrane protein
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 10
• Total formula weight: 689725.40

Authors

Zhao, C.,MacKinnon, R. (deposition date: 2022-06-19, release date: 2022-11-02, Last modification date: 2024-06-12)

• Primary citation: Zhao, C.,MacKinnon, R.; Structural and functional analyses of a GPCR-inhibited ion channel TRPM3.; Neuron, 111:81-, 2023; PubMed: 36283409; DOI: 10.1016/j.neuron.2022.10.002

Experimental method

ELECTRON MICROSCOPY (3.8 Å)