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8DDX

cryo-EM structure of TRPM3 ion channel in complex with Gbg in the presence of PIP2, tethered by ALFA-nanobody

Functional Information from GO Data
ChainGOidnamespacecontents
A0005216molecular_functionmonoatomic ion channel activity
A0006811biological_processmonoatomic ion transport
A0016020cellular_componentmembrane
A0051262biological_processprotein tetramerization
A0055085biological_processtransmembrane transport
B0005216molecular_functionmonoatomic ion channel activity
B0006811biological_processmonoatomic ion transport
B0016020cellular_componentmembrane
B0051262biological_processprotein tetramerization
B0055085biological_processtransmembrane transport
C0005216molecular_functionmonoatomic ion channel activity
C0006811biological_processmonoatomic ion transport
C0016020cellular_componentmembrane
C0051262biological_processprotein tetramerization
C0055085biological_processtransmembrane transport
D0005216molecular_functionmonoatomic ion channel activity
D0006811biological_processmonoatomic ion transport
D0016020cellular_componentmembrane
D0051262biological_processprotein tetramerization
D0055085biological_processtransmembrane transport
I0001750cellular_componentphotoreceptor outer segment
I0003924molecular_functionGTPase activity
I0005515molecular_functionprotein binding
I0005737cellular_componentcytoplasm
I0005765cellular_componentlysosomal membrane
I0005829cellular_componentcytosol
I0005834cellular_componentheterotrimeric G-protein complex
I0005886cellular_componentplasma membrane
I0007165biological_processsignal transduction
I0007186biological_processG protein-coupled receptor signaling pathway
I0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
I0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
I0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
I0007265biological_processRas protein signal transduction
I0008283biological_processcell population proliferation
I0016020cellular_componentmembrane
I0030159molecular_functionsignaling receptor complex adaptor activity
I0044877molecular_functionprotein-containing complex binding
I0045202cellular_componentsynapse
I0050909biological_processsensory perception of taste
I0051020molecular_functionGTPase binding
I0060041biological_processretina development in camera-type eye
I0070062cellular_componentextracellular exosome
I0071380biological_processcellular response to prostaglandin E stimulus
I0071870biological_processcellular response to catecholamine stimulus
I0097381cellular_componentphotoreceptor disc membrane
I1903561cellular_componentextracellular vesicle
J0005515molecular_functionprotein binding
J0005834cellular_componentheterotrimeric G-protein complex
J0005886cellular_componentplasma membrane
J0007165biological_processsignal transduction
J0007186biological_processG protein-coupled receptor signaling pathway
J0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
J0016020cellular_componentmembrane
J0031681molecular_functionG-protein beta-subunit binding
J0045202cellular_componentsynapse
J0048144biological_processfibroblast proliferation
J0070062cellular_componentextracellular exosome
J0071380biological_processcellular response to prostaglandin E stimulus
J0071870biological_processcellular response to catecholamine stimulus
Functional Information from PROSITE/UniProt
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
ILEU70-SER84
IILE157-ILE171
ILEU285-ALA299

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378
ChainResidueDetails
JALA2
BVAL895-GLU918
CVAL895-GLU918
DVAL895-GLU918

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Cysteine methyl ester => ECO:0000250|UniProtKB:P63212
ChainResidueDetails
JSER68
CLEU986-ILE989
CGLU1057-ARG1073
CALA1102-ILE1111
DLYS919-MET925
DLEU986-ILE989
DGLU1057-ARG1073
DALA1102-ILE1111
ALEU986-ILE989
AGLU1057-ARG1073
AALA1102-ILE1111
BLYS919-MET925
BLEU986-ILE989
BGLU1057-ARG1073
BALA1102-ILE1111
CLYS919-MET925

site_idSWS_FT_FI3
Number of Residues1
DetailsLIPID: S-geranylgeranyl cysteine => ECO:0000250|UniProtKB:P63212
ChainResidueDetails
JSER68
BSER926-LEU948
CSER926-LEU948
DSER926-LEU948

site_idSWS_FT_FI4
Number of Residues116
DetailsTOPO_DOM: Cytoplasmic => ECO:0000305
ChainResidueDetails
AILE949-ASP964
AVAL1014-ARG1028
BILE949-ASP964
BVAL1014-ARG1028
CILE949-ASP964
CVAL1014-ARG1028
DILE949-ASP964
DVAL1014-ARG1028

site_idSWS_FT_FI5
Number of Residues80
DetailsTRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:36283409
ChainResidueDetails
AGLN965-ARG985
BGLN965-ARG985
CGLN965-ARG985
DGLN965-ARG985

site_idSWS_FT_FI6
Number of Residues92
DetailsTRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:36283409
ChainResidueDetails
APHE990-PHE1013
BPHE990-PHE1013
CPHE990-PHE1013
DPHE990-PHE1013

site_idSWS_FT_FI7
Number of Residues108
DetailsTRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:36283409
ChainResidueDetails
AGLN1029-GLY1056
BGLN1029-GLY1056
CGLN1029-GLY1056
DGLN1029-GLY1056

site_idSWS_FT_FI8
Number of Residues108
DetailsINTRAMEM: Pore-forming => ECO:0000305|PubMed:32780479
ChainResidueDetails
AGLU1074-VAL1101
BGLU1074-VAL1101
CGLU1074-VAL1101
DGLU1074-VAL1101

site_idSWS_FT_FI9
Number of Residues100
DetailsTRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:36283409
ChainResidueDetails
AALA1112-ILE1137
BALA1112-ILE1137
CALA1112-ILE1137
DALA1112-ILE1137

site_idSWS_FT_FI10
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:36283409, ECO:0007744|PDB:8DDU
ChainResidueDetails
AASP796
BASP796
CASP796
DASP796

site_idSWS_FT_FI11
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:36283409, ECO:0007744|PDB:8DDT, ECO:0007744|PDB:8DDU
ChainResidueDetails
AMET1017
ALEU1018
BMET1017
BLEU1018
CMET1017
CLEU1018
DMET1017
DLEU1018

236620

PDB entries from 2025-05-28

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