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4RNN	Crystal structure of human polymerase eta inserting dGMPnPP opposite DNA template containing an abasic site Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA polymerase eta, GLYCEROL, ... Authors: Patra, A, Egli, M. Deposit date: 2014-10-24 Release date: 2015-02-18 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.808 Å) Cite: Structural and Kinetic Analysis of Nucleoside Triphosphate Incorporation Opposite an Abasic Site by Human Translesion DNA Polymerase eta. J.Biol.Chem., 290, 2015
4RU9	Crystal structure of human DNA polymerase eta inserting dCMPNPP opposite a MeFapy-dG adducted DNA template Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA polymerase eta, MAGNESIUM ION, ... Authors: Patra, A, Egli, M. Deposit date: 2014-11-18 Release date: 2015-08-05 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Structural Basis for Error-Free Bypass of the 5-N-Methylformamidopyrimidine-dG Lesion by Human DNA Polymerase eta and Sulfolobus solfataricus P2 Polymerase IV. J.Am.Chem.Soc., 137, 2015
4RNM	Crystal structure of human polymerase eta inserting dAMPnPP opposite DNA template containing an abasic site Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA Primar: AGCGTCAT, DNA Template: CAT(3DR)ATGACGCT, ... Authors: Patra, A, Egli, M. Deposit date: 2014-10-24 Release date: 2015-02-18 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.144 Å) Cite: Structural and Kinetic Analysis of Nucleoside Triphosphate Incorporation Opposite an Abasic Site by Human Translesion DNA Polymerase eta. J.Biol.Chem., 290, 2015
4RNO	Crystal structure of human polymerase eta extending an abasic site-dA pair by inserting dCTP opposite template G Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA polymerase eta, ... Authors: Patra, A, Egli, M. Deposit date: 2014-10-24 Release date: 2015-02-18 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.82 Å) Cite: Structural and Kinetic Analysis of Nucleoside Triphosphate Incorporation Opposite an Abasic Site by Human Translesion DNA Polymerase eta. J.Biol.Chem., 290, 2015
4Q8E	Human DNA polymerase eta inserting dCMPNPP opposite a phenanthriplatin adducted G Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, 5'-D(*AP*GP*TP*GP*TP*GP*AP*G)-3', 5'-D(*CP*AP*TP*GP*CP*TP*CP*AP*CP*AP*CP*T)-3', ... Authors: Gregory, M.T, Yang, W. Deposit date: 2014-04-26 Release date: 2014-07-02 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.549 Å) Cite: Structural and mechanistic studies of polymerase eta bypass of phenanthriplatin DNA damage. Proc.Natl.Acad.Sci.USA, 111, 2014
4Q8F	Human DNA polymerase eta extending primer immediately after a phenanthriplatin adducted G Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, 5'-D(*AP*GP*TP*GP*TP*GP*AP*C)-3', 5'-D(*CP*AP*TP*CP*GP*TP*CP*AP*CP*AP*CP*T)-3', ... Authors: Gregory, M.T, Yang, W. Deposit date: 2014-04-26 Release date: 2014-07-02 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.797 Å) Cite: Structural and mechanistic studies of polymerase eta bypass of phenanthriplatin DNA damage. Proc.Natl.Acad.Sci.USA, 111, 2014
8G8H	Crystal structure of human DNA polymerase eta incorporating ITP across dC Descriptor: CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*GP*AP*G)-3'), DNA (5'-D(P*AP*TP*CP*CP*TP*CP*AP*CP*GP*CP*T)-3'), ... Authors: Jung, H. Deposit date: 2023-02-17 Release date: 2024-02-21 Method: X-RAY DIFFRACTION (1.64 Å) Cite: Crystal structure of human DNA polymerase eta incorporating ITP across dC To Be Published
8GML	Crystal structure of human DNA polymerase eta incorporating 5F-dUTP across dG Descriptor: 2'-deoxy-5-fluorouridine 5'-(tetrahydrogen triphosphate), CALCIUM ION, DNA (5'-D(*AP*GP*TP*GP*TP*GP*AP*G)-3'), ... Authors: Jung, H. Deposit date: 2023-03-26 Release date: 2023-09-20 Method: X-RAY DIFFRACTION (2.567 Å) Cite: Crystal structure of human DNA polymerase eta incorporating 5F-dUTP across dA To Be Published
8GKR	Crystal structure of human DNA polymerase eta incorporating 5F-dUTP across dA Descriptor: 2'-deoxy-5-fluorouridine 5'-(tetrahydrogen triphosphate), CALCIUM ION, DNA (5'-D(*AP*GP*TP*GP*TP*GP*AP*G)-3'), ... Authors: Jung, H. Deposit date: 2023-03-20 Release date: 2023-09-20 Method: X-RAY DIFFRACTION (2.784 Å) Cite: Crystal structure of human DNA polymerase eta incorporating 5F-dUTP across dA To Be Published
8G8J	Crystal structure of human DNA polymerase eta incorporating ITP across dT Descriptor: CALCIUM ION, DNA (5'-D(*AP*GP*TP*GP*TP*GP*AP*G)-3'), DNA (5'-D(P*AP*TP*TP*CP*TP*CP*AP*CP*AP*CP*T)-3'), ... Authors: Jung, H. Deposit date: 2023-02-17 Release date: 2024-02-21 Method: X-RAY DIFFRACTION (1.74 Å) Cite: Crystal structure of human DNA polymerase eta incorporating ITP across dT To Be Published
8GBF	Crystal structure of human DNA polymerase eta incorporating syn-ITP across dT Descriptor: CALCIUM ION, DNA (5'-D(*AP*GP*TP*GP*TP*GP*AP*G)-3'), DNA (5'-D(P*AP*TP*TP*CP*TP*CP*AP*CP*AP*CP*T)-3'), ... Authors: Jung, H. Deposit date: 2023-02-25 Release date: 2024-02-28 Method: X-RAY DIFFRACTION (2.11 Å) Cite: Crystal structure of human DNA polymerase eta incorporating syn-ITP across dT To Be Published
4YR3	Mutant Human DNA Polymerase Eta R61M Inserting dCTP Opposite Template G Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... Authors: Su, Y, Patra, A, Harp, J.M, Egli, M, Guengerich, F.P. Deposit date: 2015-03-14 Release date: 2015-05-13 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2 Å) Cite: Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase eta in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2'-deoxyguanosine. J.Biol.Chem., 290, 2015
4YP3	Mutant Human DNA Polymerase Eta Q38A/R61A Inserting dCTP Opposite an 8-Oxoguanine Lesion Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... Authors: Su, Y, Patra, A, Harp, J.M, Egli, M, Guengerich, F.P. Deposit date: 2015-03-12 Release date: 2015-05-13 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.89 Å) Cite: Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase eta in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2'-deoxyguanosine. J.Biol.Chem., 290, 2015
4YR2	Mutant Human DNA Polymerase Eta R61M Inserting dATP Opposite an 8-Oxoguanine Lesion Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... Authors: Su, Y, Patra, A, Harp, J.M, Egli, M, Guengerich, F.P. Deposit date: 2015-03-14 Release date: 2015-05-13 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase eta in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2'-deoxyguanosine. J.Biol.Chem., 290, 2015
4YR0	Mutant Human DNA Polymerase Eta R61M Inserting dCTP Opposite an 8-Oxoguanine Lesion Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... Authors: Su, Y, Patra, A, Harp, J.M, Egli, M, Guengerich, F.P. Deposit date: 2015-03-13 Release date: 2015-05-13 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.78 Å) Cite: Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase eta in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2'-deoxyguanosine. J.Biol.Chem., 290, 2015
4YQW	Mutant Human DNA Polymerase Eta Q38A/R61A Inserting dCTP Opposite Template G Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... Authors: Su, Y, Patra, A, Harp, J.M, Egli, M, Guengerich, F.P. Deposit date: 2015-03-13 Release date: 2015-05-13 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.064 Å) Cite: Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase eta in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2'-deoxyguanosine. J.Biol.Chem., 290, 2015
3OHA	Yeast DNA polymerase eta inserting dCTP opposite an 8oxoG lesion Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 5'-D(*GP*TP*CP*CP*TP*CP*CP*CP*CP*TP*(DOC))-3', 5'-D(P*TP*(8OG)P*GP*AP*GP*GP*GP*GP*AP*GP*GP*AP*C)-3', ... Authors: Silverstein, T.D, Jain, R, Aggarwal, A.K. Deposit date: 2010-08-17 Release date: 2010-12-22 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural basis for error-free replication of oxidatively damaged DNA by yeast DNA polymerase eta. Structure, 18, 2010
3OHB	Yeast DNA polymerase eta extending from an 8-oxoG lesion Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 5'-D(*GP*TP*CP*CP*TP*CP*CP*CP*CP*TP*(DOC))-3', 5'-D(*TP*AP*AP*TP*GP*(8OG)P*AP*GP*GP*GP*GP*AP*GP*GP*AP*C)-3', ... Authors: Silverstein, T.D, Jain, R, Aggarwal, A.K. Deposit date: 2010-08-17 Release date: 2010-12-22 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural basis for error-free replication of oxidatively damaged DNA by yeast DNA polymerase eta. Structure, 18, 2010
6M7T	Human DNA polymerase eta in a non-productive ternary complex with Ca2+ and dTTP oppositing cdA Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, DNA (5'-D(*AP*GP*TP*GP*TP*GP*AP*G)-3'), ... Authors: Weng, P, Gao, Y, Yang, W. Deposit date: 2018-08-21 Release date: 2018-09-12 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Bypassing a 8,5'-cyclo-2'-deoxyadenosine lesion by human DNA polymerase eta at atomic resolution. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6M7U	Human DNA polymerase eta in a non-productive ternary complex with Mg2+ and dTMPNPP oppositing cdA Descriptor: 5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]thymidine, CHLORIDE ION, DNA (5'-D(*AP*GP*TP*GP*TP*GP*AP*G)-3'), ... Authors: Weng, P, Gao, Y, Yang, W. Deposit date: 2018-08-21 Release date: 2018-09-12 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (3.4 Å) Cite: Bypassing a 8,5'-cyclo-2'-deoxyadenosine lesion by human DNA polymerase eta at atomic resolution. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6M7P	Human DNA polymerase eta extension complex with cdA at the -2 position Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*AP*GP*TP*GP*TP*GP*TP*G)-3'), DNA (5'-D(*CP*AP*TP*TP*CP*(02I)P*CP*AP*CP*AP*CP*T)-3'), ... Authors: Gregory, M.T, Yang, W. Deposit date: 2018-08-20 Release date: 2018-09-12 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Bypassing a 8,5'-cyclo-2'-deoxyadenosine lesion by human DNA polymerase eta at atomic resolution. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6M7O	Human DNA polymerase eta ternary complex with Mn2+ and dTMPNPP oppositing cdA Descriptor: 5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]thymidine, DNA (5'-D(*AP*TP*(02I)P*CP*TP*CP*AP*CP*AP*CP*T)-3'), DNA (5'-D(P*AP*GP*TP*GP*TP*GP*AP*G*(1FZ))-3'), ... Authors: Weng, P, Gao, Y, Yang, W. Deposit date: 2018-08-20 Release date: 2018-09-12 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (3 Å) Cite: Bypassing a 8,5'-cyclo-2'-deoxyadenosine lesion by human DNA polymerase eta at atomic resolution. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6MXO	Structure of HPoleta incorporating dCTP opposite the 3-prime Pt(DACH)-GG Descriptor: (cyclohex-1-ene-1,2-diamine)platinum(2+), 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(*AP*CP*GP*GP*CP*TP*CP*AP*CP*AP*CP*T)-3'), ... Authors: Ouzon-Shubeita, H, Lee, S. Deposit date: 2018-10-31 Release date: 2019-02-13 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.04 Å) Cite: Structural basis for the bypass of the major oxaliplatin-DNA adducts by human DNA polymerase eta. Biochem. J., 476, 2019
6MP3	Binary structure of DNA polymerase eta in complex with templating hypoxanthine Descriptor: DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*IP*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA polymerase eta, ... Authors: Hawkins, M.A, Jung, H, Lee, S. Deposit date: 2018-10-05 Release date: 2019-10-16 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.907 Å) Cite: Structural Analysis of Translesion Synthesis Across Hypoxanthine Lesion Using Human DNA Polymerase Eta To Be Published
6M7V	Human DNA polymerase eta extension complex with cdA at the -1 position Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(P*(02I)P*CP*TP*CP*AP*CP*AP*CP*T)-3'), DNA (5'-D(P*GP*TP*GP*TP*GP*AP*GP*T)-3'), ... Authors: Weng, P, Gao, Y, Yang, W. Deposit date: 2018-08-21 Release date: 2018-09-12 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (3.062 Å) Cite: Bypassing a 8,5'-cyclo-2'-deoxyadenosine lesion by human DNA polymerase eta at atomic resolution. Proc. Natl. Acad. Sci. U.S.A., 115, 2018

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