4YR0

Mutant Human DNA Polymerase Eta R61M Inserting dCTP Opposite an 8-Oxoguanine Lesion

Summary for 4YR0

• Entry DOI: 10.2210/pdb4yr0/pdb
• Related: 4YQW 4YR2 4YR3
• Descriptor: DNA polymerase eta, DNA (5'-D(P*TP*(8OG)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... (7 entities in total)
• Functional Keywords: dctp 8-oxoguanine, transferase-dna complex, transferase/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 55428.23

Authors

Su, Y.,Patra, A.,Harp, J.M.,Egli, M.,Guengerich, F.P. (deposition date: 2015-03-13, release date: 2015-05-13, Last modification date: 2023-09-27)

• Primary citation: Su, Y.,Patra, A.,Harp, J.M.,Egli, M.,Guengerich, F.P.; Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase eta in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2'-deoxyguanosine.; J.Biol.Chem., 290:15921-15933, 2015; PubMed: 25947374; DOI: 10.1074/jbc.M115.653691

Experimental method

X-RAY DIFFRACTION (1.78 Å)