4YR0

Mutant Human DNA Polymerase Eta R61M Inserting dCTP Opposite an 8-Oxoguanine Lesion

Summary for 4YR0

Related4YQW 4YR3 4YR2
DescriptorDNA polymerase eta, DNA (5'-D(P*TP*(8OG)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... (7 entities in total)
Functional Keywordsdctp 8-oxoguanine, transferase-dna complex, transferase/dna
Biological sourceHomo sapiens (Human)
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Cellular locationNucleus  Q9Y253
Total number of polymer chains3
Total molecular weight55428.23
Authors
Su, Y.,Patra, A.,Harp, J.M.,Egli, M.,Guengerich, F.P. (deposition date: 2015-03-13, release date: 2015-05-13, Last modification date: 2017-09-20)
Primary citation
Su, Y.,Patra, A.,Harp, J.M.,Egli, M.,Guengerich, F.P.
Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase eta in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2'-deoxyguanosine.
J.Biol.Chem., 290:15921-15933, 2015
PubMed: 25947374 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M115.653691
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.78 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2122004.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 4yr0
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Molmil generated image of 4yr0
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Molmil generated image of 4yr0
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