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4YR0

Mutant Human DNA Polymerase Eta R61M Inserting dCTP Opposite an 8-Oxoguanine Lesion

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1ADNA polymerase etapolymer43548591.71UniProt (Q9Y253)
Pfam (PF00817)
Pfam (PF21704)
Pfam (PF11799)
In PDB
Homo sapiens (Human)RAD30 homolog A,Xeroderma pigmentosum variant type protein
2TDNA (5'-D(P*TP*(8OG)P*AP*TP*GP*AP*CP*GP*CP*T)-3')polymer123678.41synthetic construct
3PDNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3')polymer82426.61synthetic construct
4A2'-DEOXYCYTIDINE-5'-TRIPHOSPHATEnon-polymer467.21Chemie (DCP)
5ACALCIUM IONnon-polymer40.12Chemie (CA)
6AGLYCEROLnon-polymer92.12Chemie (GOL)
7waterwater18.0481Chemie (HOH)
Sequence modifications
A: 1 - 432 (UniProt: Q9Y253)
PDBExternal DatabaseDetails
Gly -2-expression tag
Pro -1-expression tag
His 0-expression tag
Met 61Arg 61engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains3
Total formula weight54696.7
Non-Polymers*Number of molecules5
Total formula weight731.5
All*Total formula weight55428.2
*Water molecules are not included.

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PDB entries from 2024-09-18

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