Mutant Human DNA Polymerase Eta Q38A/R61A Inserting dCTP Opposite an 8-Oxoguanine Lesion

Summary for 4YP3

DescriptorDNA polymerase eta, DNA (5'-D(*TP*(8OG)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... (7 entities in total)
Functional Keywordshuman dna polymerase eta q38a/r61a mutation 8-oxoguanine dctp, transferase-dna complex, transferase/dna
Biological sourceHomo sapiens (Human)
Total number of polymer chains3
Total molecular weight55311.06
Su, Y.,Patra, A.,Harp, J.M.,Egli, M.,Guengerich, F.P. (deposition date: 2015-03-12, release date: 2015-05-13, Last modification date: 2019-12-04)
Primary citation
Su, Y.,Patra, A.,Harp, J.M.,Egli, M.,Guengerich, F.P.
Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase eta in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2'-deoxyguanosine.
J.Biol.Chem., 290:15921-15933, 2015
PubMed: 25947374 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M115.653691
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.216200.6%5.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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