4YP3
Mutant Human DNA Polymerase Eta Q38A/R61A Inserting dCTP Opposite an 8-Oxoguanine Lesion
Summary for 4YP3
Entry DOI | 10.2210/pdb4yp3/pdb |
Descriptor | DNA polymerase eta, DNA (5'-D(*TP*(8OG)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... (7 entities in total) |
Functional Keywords | human dna polymerase eta q38a/r61a mutation 8-oxoguanine dctp, transferase-dna complex, transferase/dna |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 55311.06 |
Authors | Su, Y.,Patra, A.,Harp, J.M.,Egli, M.,Guengerich, F.P. (deposition date: 2015-03-12, release date: 2015-05-13, Last modification date: 2023-09-27) |
Primary citation | Su, Y.,Patra, A.,Harp, J.M.,Egli, M.,Guengerich, F.P. Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase eta in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2'-deoxyguanosine. J.Biol.Chem., 290:15921-15933, 2015 Cited by PubMed: 25947374DOI: 10.1074/jbc.M115.653691 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.89 Å) |
Structure validation
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