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2HDP
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BU of 2hdp by Molmil
Solution Structure of Hdm2 RING Finger Domain
Descriptor: Ubiquitin-protein ligase E3 Mdm2, ZINC ION
Authors:Kostic, M, Matt, T, Yamout-Martinez, M, Dyson, H.J, Wright, P.E.
Deposit date:2006-06-20
Release date:2006-11-21
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Solution structure of the Hdm2 C2H2C4 RING, a domain critical for ubiquitination of p53.
J.Mol.Biol., 363, 2006
3SHV
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BU of 3shv by Molmil
Crystal structure of human MCPH1 tandem BRCT domains-gamma H2AX complex
Descriptor: Histone H2A.x, Microcephalin
Authors:Shao, Z.H, Li, F.D, Yan, W.
Deposit date:2011-06-17
Release date:2011-12-28
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Specific recognition of phosphorylated tail of H2AX by the tandem BRCT domains of MCPH1 revealed by complex structure
J.Struct.Biol., 177, 2012
3SQD
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BU of 3sqd by Molmil
Crystal structure of human PTIP BRCT5/6-gamma H2AX complex
Descriptor: Histone H2A.x, PAX-interacting protein 1
Authors:Yan, W, Shao, Z.H.
Deposit date:2011-07-05
Release date:2011-11-09
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.153 Å)
Cite:Crystal structure of human PTIP BRCT5/6-gamma H2AX
To be Published
2JQJ
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BU of 2jqj by Molmil
NMR structure of yeast Dun1 FHA domain
Descriptor: DNA damage response protein kinase DUN1
Authors:Yuan, C, Lee, H, Chang, C, Heierhorst, J, Tsai, M.
Deposit date:2007-06-02
Release date:2008-06-24
Last modified:2023-12-20
Method:SOLUTION NMR
Cite:Diphosphothreonine-specific interaction between an SQ/TQ cluster and an FHA domain in the Rad53-Dun1 kinase cascade.
Mol.Cell, 30, 2008
7VQQ
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BU of 7vqq by Molmil
Cryo-EM structure of amyloid fibril formed by FUS low complexity domain
Descriptor: fusion protein of mCerulean and FUS LCD
Authors:Sun, Y.P, Xia, W.C, Liu, C.
Deposit date:2021-10-20
Release date:2021-12-22
Last modified:2022-02-23
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Molecular structure of an amyloid fibril formed by FUS low-complexity domain.
Iscience, 25, 2022
2PKV
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BU of 2pkv by Molmil
D-(GGTATACC) ambient pressure
Descriptor: 5'-D(*GP*GP*TP*AP*TP*AP*CP*C)-3'
Authors:Girard, E, Prange, T, Kahn, R, Fourme, R.
Deposit date:2007-04-18
Release date:2007-07-24
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Adaptation of the base-paired double-helix molecular architecture to extreme pressure.
Nucleic Acids Res., 35, 2007
2PLB
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BU of 2plb by Molmil
D(GTATACC) under hydrostatic pressure of 1.39 GPa
Descriptor: 5'-D(*DGP*DGP*DTP*DAP*DTP*DAP*DCP*DC)-3', SPERMINE
Authors:Prange, T, Girard, E, Kahn, R, Fourme, R.
Deposit date:2007-04-19
Release date:2007-07-24
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Adaptation of the base-paired double-helix molecular architecture to extreme pressure.
Nucleic Acids Res., 35, 2007
2PL4
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BU of 2pl4 by Molmil
D-(GGTATACC) under 0.55 GPa hydrostatic pressure
Descriptor: Synthetic DNA octamer
Authors:Prange, T, Girard, E, Kahn, R, Fourme, R.
Deposit date:2007-04-19
Release date:2007-07-24
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Adaptation of the base-paired double-helix molecular architecture to extreme pressure.
Nucleic Acids Res., 35, 2007
2PL8
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BU of 2pl8 by Molmil
D(GTATACC) under hydrostatic pressure of 1.04 GPa
Descriptor: 5'-D(*DGP*DGP*DTP*DAP*DTP*DAP*DCP*DC)-3', SPERMINE
Authors:Prange, T, Girard, E, Fourme, R, Kahn, R.
Deposit date:2007-04-19
Release date:2007-07-24
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Adaptation of the base-paired double-helix molecular architecture to extreme pressure.
Nucleic Acids Res., 35, 2007
7XZZ
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BU of 7xzz by Molmil
Cryo-EM structure of the nucleosome in complex with p53
Descriptor: Cellular tumor antigen p53, DNA (169-MER), Histone H2A type 1-B/E, ...
Authors:Nishimura, M, Nozawa, K, Takizawa, Y, Kurumizaka, H.
Deposit date:2022-06-03
Release date:2022-10-12
Last modified:2023-02-15
Method:ELECTRON MICROSCOPY (4.07 Å)
Cite:Structural basis for p53 binding to its nucleosomal target DNA sequence.
Pnas Nexus, 1, 2022
7XV4
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BU of 7xv4 by Molmil
Crystal structure of RPA70N-ATRIP fusion
Descriptor: ATR-interacting protein, Replication protein A 70 kDa DNA-binding subunit
Authors:Wu, Y.Y, Zang, N, Fu, W.M, Zhou, C.
Deposit date:2022-05-20
Release date:2023-06-14
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural characterization of human RPA70N association with DNA damage response proteins.
Elife, 12, 2023
7YXA
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BU of 7yxa by Molmil
XFEL crystal structure of the human sphingosine 1 phosphate receptor 5 in complex with ONO-5430608
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[6-(2-naphthalen-1-ylethoxy)-2,3,4,5-tetrahydro-1H-3-benzazepin-3-ium-3-yl]butanoic acid, ...
Authors:Lyapina, E, Marin, E, Gusach, A, Orekhov, P, Gerasimov, A, Luginina, A, Vakhrameev, D, Ergasheva, M, Kovaleva, M, Khusainov, G, Khorn, P, Shevtsov, M, Kovalev, K, Okhrimenko, I, Bukhdruker, S, Popov, P, Hu, H, Weierstall, U, Liu, W, Cho, Y, Gushchin, I, Rogachev, A, Bourenkov, G, Park, S, Park, G, Huyn, H.J, Park, J, Gordeliy, V, Borshchevskiy, V, Mishin, A, Cherezov, V.
Deposit date:2022-02-15
Release date:2022-08-10
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis for receptor selectivity and inverse agonism in S1P 5 receptors.
Nat Commun, 13, 2022
5GOX
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BU of 5gox by Molmil
Eukaryotic Rad50 Functions as A Rod-shaped Dimer
Descriptor: DNA repair protein RAD50, GLYCEROL, ZINC ION
Authors:Park, Y.B, Hohl, M, Padjasek, M, Jeong, E, Jin, K.S, Krezel, A, Petrini, J.H.J, Cho, Y.
Deposit date:2016-07-30
Release date:2017-02-01
Last modified:2017-03-15
Method:X-RAY DIFFRACTION (2.405 Å)
Cite:Eukaryotic Rad50 functions as a rod-shaped dimer
Nat. Struct. Mol. Biol., 24, 2017
5HPD
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BU of 5hpd by Molmil
Solution Structure of TAZ2-p53TAD
Descriptor: CREB-binding protein,Cellular tumor antigen p53 fusion protein, ZINC ION
Authors:Krois, A.S, Ferreon, J.C, Martinez-Yamout, M.A, Dyson, H.J, Wright, P.E.
Deposit date:2016-01-20
Release date:2016-03-16
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Recognition of the disordered p53 transactivation domain by the transcriptional adapter zinc finger domains of CREB-binding protein.
Proc.Natl.Acad.Sci.USA, 113, 2016
5HOU
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BU of 5hou by Molmil
Solution Structure of p53TAD-TAZ1
Descriptor: Cellular tumor antigen p53,CREB-binding protein fusion protein, ZINC ION
Authors:Krois, A.S, Ferreon, J.C, Martinez-Yamout, M.A, Dyson, H.J, Wright, P.E.
Deposit date:2016-01-19
Release date:2016-03-16
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Recognition of the disordered p53 transactivation domain by the transcriptional adapter zinc finger domains of CREB-binding protein.
Proc.Natl.Acad.Sci.USA, 113, 2016
7CMZ
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BU of 7cmz by Molmil
Crystal Structure of BRCT7/8 in Complex with the APS Motif of PHF8
Descriptor: DNA topoisomerase 2-binding protein 1, Histone lysine demethylase PHF8, POTASSIUM ION, ...
Authors:Che, S.Y, Ma, S, Cao, C, Yao, Z, Shi, L, Yang, N.
Deposit date:2020-07-29
Release date:2021-03-17
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.695 Å)
Cite:PHF8-promoted TOPBP1 demethylation drives ATR activation and preserves genome stability.
Sci Adv, 7, 2021
5GHD
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BU of 5ghd by Molmil
SOLUTION STRUCTURE OF LYS39 ACETYLATED HUMAN SUMO1
Descriptor: Small ubiquitin-related modifier 1
Authors:Naik, M.T, Naik, N, Shih, H, Huang, T.
Deposit date:2016-06-19
Release date:2017-06-07
Last modified:2023-11-15
Method:SOLUTION NMR
Cite:Structures of Human Sumo
To Be Published
7AI0
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BU of 7ai0 by Molmil
Crystal structure of human MDM2-G443T RING domain homodimer bound to UbcH5B-Ub (Crystal form 1)
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, ...
Authors:Magnussen, H.M, Huang, D.T.
Deposit date:2020-09-25
Release date:2021-01-20
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.559 Å)
Cite:Identification of a Catalytic Active but Non-Aggregating MDM2 RING Domain Variant.
J.Mol.Biol., 433, 2021
7AI1
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BU of 7ai1 by Molmil
Crystal structure of human MDM2-G443T RING domain homodimer bound to UbcH5B-Ub (Crystal form 2)
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, ...
Authors:Magnussen, H.M, Huang, D.T.
Deposit date:2020-09-25
Release date:2021-01-20
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Identification of a Catalytic Active but Non-Aggregating MDM2 RING Domain Variant.
J.Mol.Biol., 433, 2021
7AKH
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BU of 7akh by Molmil
Structure of DYRK2 in complex with compound 58
Descriptor: 4-[3-[(2~{S})-2-(6-bromanylpyridin-2-yl)oxypropyl]-2-methyl-imidazo[4,5-b]pyridin-5-yl]pyridine-2,6-diamine, CHLORIDE ION, Dual specificity tyrosine-phosphorylation-regulated kinase 2
Authors:Dokurno, P, Surgenor, A.E, Kotschy, A.
Deposit date:2020-10-01
Release date:2021-05-26
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structure-Guided Discovery of Potent and Selective DYRK1A Inhibitors.
J.Med.Chem., 64, 2021
7AKF
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BU of 7akf by Molmil
Structure of DYRK2 in complex with compound 50
Descriptor: 4-(2,3-dimethyl-1-benzofuran-5-yl)pyridine-2,6-diamine, CHLORIDE ION, Dual specificity tyrosine-phosphorylation-regulated kinase 2
Authors:Dokurno, P, Surgenor, A.E, Kotschy, A.
Deposit date:2020-09-30
Release date:2021-05-26
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure-Guided Discovery of Potent and Selective DYRK1A Inhibitors.
J.Med.Chem., 64, 2021
2AZM
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BU of 2azm by Molmil
Crystal structure of the MDC1 brct repeat in complex with the histone tail of gamma-H2AX
Descriptor: GAMMA-H2AX HISTONE, Mediator of DNA damage checkpoint protein 1
Authors:Clapperton, J.A, Stucki, M, Mohammad, D, Yaffe, M.B, Jackson, S.P, Smerdon, S.J.
Deposit date:2005-09-12
Release date:2006-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:MDC1 Directly Binds Phosphorylated Histone H2AX to Regulate Cellular Responses to DNA Double-Strand Breaks
Cell(Cambridge,Mass.), 123, 2005
2DKH
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BU of 2dkh by Molmil
Crystal structure of 3-hydroxybenzoate hydroxylase from Comamonas testosteroni, in complex with the substrate
Descriptor: 3-HYDROXYBENZOIC ACID, 3-hydroxybenzoate hydroxylase, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Hiromoto, T, Fujiwara, S, Hosokawa, K, Yamaguchi, H.
Deposit date:2006-04-11
Release date:2006-10-24
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of 3-hydroxybenzoate hydroxylase from Comamonas testosteroni has a large tunnel for substrate and oxygen access to the active site
J.Mol.Biol., 364, 2006
6UVQ
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BU of 6uvq by Molmil
Crystal structure of Apo AtmM
Descriptor: ACETATE ION, D-glucose O-methyltransferase, MAGNESIUM ION
Authors:Alvarado, S.K, Wang, Z, Miller, M.D, Thorson, J.S, Phillips Jr, G.N.
Deposit date:2019-11-04
Release date:2020-11-25
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Structure of Apo AtmM
To Be Published
6UWD
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BU of 6uwd by Molmil
Crystal structure of Apo AtmM
Descriptor: ACETATE ION, D-glucose O-methyltransferase, MAGNESIUM ION
Authors:Alvarado, S.K, Wang, Z, Miller, M.D, Thorson, J.S, Phillips Jr, G.N.
Deposit date:2019-11-05
Release date:2020-11-25
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Structure of Apo AtmM
To Be Published

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數據於2024-06-19公開中

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