8D76
Crystal Structure of EGFR LRTM with compound 24
Summary for 8D76
Entry DOI | 10.2210/pdb8d76/pdb |
Descriptor | Epidermal growth factor receptor, GLYCEROL, (3S,4R)-3-fluoro-1-(4-{[8-{3-[(methanesulfonyl)methyl]azetidin-1-yl}-5-(propan-2-yl)-2,7-naphthyridin-3-yl]amino}pyrimidin-2-yl)-3-methylpiperidin-4-ol, ... (4 entities in total) |
Functional Keywords | protein kinase, inhibitor, kinase domain, mutation, signaling protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 81235.43 |
Authors | Kim, J.L. (deposition date: 2022-06-07, release date: 2022-07-27, Last modification date: 2023-10-18) |
Primary citation | Eno, M.S.,Brubaker, J.D.,Campbell, J.E.,De Savi, C.,Guzi, T.J.,Williams, B.D.,Wilson, D.,Wilson, K.,Brooijmans, N.,Kim, J.,Ozen, A.,Perola, E.,Hsieh, J.,Brown, V.,Fetalvero, K.,Garner, A.,Zhang, Z.,Stevison, F.,Woessner, R.,Singh, J.,Timsit, Y.,Kinkema, C.,Medendorp, C.,Lee, C.,Albayya, F.,Zalutskaya, A.,Schalm, S.,Dineen, T.A. Discovery of BLU-945, a Reversible, Potent, and Wild-Type-Sparing Next-Generation EGFR Mutant Inhibitor for Treatment-Resistant Non-Small-Cell Lung Cancer. J.Med.Chem., 65:9662-9677, 2022 Cited by PubMed: 35838760DOI: 10.1021/acs.jmedchem.2c00704 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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