8D76
Crystal Structure of EGFR LRTM with compound 24
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Epidermal growth factor receptor | polymer | 348 | 39797.8 | 2 | UniProt (P00533) Pfam (PF07714) In PDB | Homo sapiens (human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
2 | A, B | GLYCEROL | non-polymer | 92.1 | 6 | Chemie (GOL) | |||
3 | A, B | (3S,4R)-3-fluoro-1-(4-{[8-{3-[(methanesulfonyl)methyl]azetidin-1-yl}-5-(propan-2-yl)-2,7-naphthyridin-3-yl]amino}pyrimidin-2-yl)-3-methylpiperidin-4-ol | non-polymer | 543.7 | 2 | Chemie (QFO) | |||
4 | water | water | 18.0 | 609 | Chemie (HOH) |
Sequence modifications
A, B: 695 - 1022 (UniProt: P00533)
PDB | External Database | Details |
---|---|---|
Met 675 | - | initiating methionine |
Gly 676 | - | expression tag |
Ser 677 | - | expression tag |
Ser 678 | - | expression tag |
His 679 | - | expression tag |
His 680 | - | expression tag |
His 681 | - | expression tag |
His 682 | - | expression tag |
His 683 | - | expression tag |
His 684 | - | expression tag |
Ser 685 | - | expression tag |
Ser 686 | - | expression tag |
Gly 687 | - | expression tag |
Glu 688 | - | expression tag |
Asn 689 | - | expression tag |
Leu 690 | - | expression tag |
Tyr 691 | - | expression tag |
Phe 692 | - | expression tag |
Gln 693 | - | expression tag |
Gly 694 | - | expression tag |
Met 790 | Thr 790 | engineered mutation |
Arg 858 | Leu 858 | engineered mutation |
Arg 948 | Val 948 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 79595.6 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 1639.9 | |
All* | Total formula weight | 81235.4 |