6WJ5

Structure of human TRPA1 in complex with inhibitor GDC-0334

Summary for 6WJ5

• Entry DOI: 10.2210/pdb6wj5/pdb
• EMDB information: 21688
• Descriptor: Transient receptor potential cation channel subfamily A member 1, (4R,5S)-4-fluoro-1-[(4-fluorophenyl)sulfonyl]-5-methyl-N-({5-(trifluoromethyl)-2-[2-(trifluoromethyl)pyrimidin-5-yl]pyridin-4-yl}methyl)-L-prolinamide (2 entities in total)
• Functional Keywords: trpa1, channel, inhibitor, antagonist, membrane protein, membrane protein-inhibitor complex, membrane protein/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 292926.47

Authors

Rohou, A.,Rouge, L.,Arthur, C.P.,Volgraf, M.,Chen, H. (deposition date: 2020-04-11, release date: 2021-02-17, Last modification date: 2021-08-11)

• Primary citation: Balestrini, A.,Joseph, V.,Dourado, M.,Reese, R.M.,Shields, S.D.,Rouge, L.,Bravo, D.D.,Chernov-Rogan, T.,Austin, C.D.,Chen, H.,Wang, L.,Villemure, E.,Shore, D.G.M.,Verma, V.A.,Hu, B.,Chen, Y.,Leong, L.,Bjornson, C.,Hotzel, K.,Gogineni, A.,Lee, W.P.,Suto, E.,Wu, X.,Liu, J.,Zhang, J.,Gandham, V.,Wang, J.,Payandeh, J.,Ciferri, C.,Estevez, A.,Arthur, C.P.,Kortmann, J.,Wong, R.L.,Heredia, J.E.,Doerr, J.,Jung, M.,Vander Heiden, J.A.,Roose-Girma, M.,Tam, L.,Barck, K.H.,Carano, R.A.D.,Ding, H.T.,Brillantes, B.,Tam, C.,Yang, X.,Gao, S.S.,Ly, J.Q.,Liu, L.,Chen, L.,Liederer, B.M.,Lin, J.H.,Magnuson, S.,Chen, J.,Hackos, D.H.,Elstrott, J.,Rohou, A.,Safina, B.S.,Volgraf, M.,Bauer, R.N.,Riol-Blanco, L.; A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment.; J.Exp.Med., 218:-, 2021; PubMed: 33620419; DOI: 10.1084/jem.20201637

Experimental method

ELECTRON MICROSCOPY (3.6 Å)