Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6WJ5

Structure of human TRPA1 in complex with inhibitor GDC-0334

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0055085	biological_process	transmembrane transport
B	0005216	molecular_function	monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0055085	biological_process	transmembrane transport
C	0005216	molecular_function	monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0055085	biological_process	transmembrane transport
D	0005216	molecular_function	monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0055085	biological_process	transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue LXY A 1101

Chain	Residue
A	LEU870
A	VAL948
A	LEU952
B	ILE946
B	ILE950
A	LEU871
A	SER873
A	THR874
A	PHE877
A	ILE878
A	LEU881
A	PHE909
A	MET912

site_id	AC2
Number of Residues	13
Details	binding site for residue LXY B 1101

Chain	Residue
B	LEU870
B	LEU871
B	THR874
B	PHE877
B	ILE878
B	LEU881
B	PHE909
B	MET912
B	PHE944
B	VAL948
B	LEU952
C	ILE946
C	ILE950

site_id	AC3
Number of Residues	14
Details	binding site for residue LXY C 1101

Chain	Residue
C	LEU870
C	LEU871
C	SER873
C	THR874
C	PHE877
C	ILE878
C	LEU881
C	PHE909
C	MET912
C	VAL948
C	LEU952
D	VAL942
D	ILE946
D	ILE950

site_id	AC4
Number of Residues	13
Details	binding site for residue LXY D 1101

Chain	Residue
A	ILE946
A	ILE950
D	LEU870
D	LEU871
D	THR874
D	PHE877
D	ILE878
D	LEU881
D	PHE909
D	MET912
D	PHE944
D	VAL948
D	LEU952

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DISDTRLLNegDL

Chain	Residue	Details
A	ASP468-LEU480

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"31866091","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PQO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	92
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"31866091","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PQO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	44
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	116
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"31866091","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PQO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	80
Details	Intramembrane: {"description":"Pore-forming","evidences":[{"source":"PubMed","id":"31866091","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PQO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	104
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"31866091","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PQO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	116
Details	Repeat: {"description":"ANK 13","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25855297","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	116
Details	Repeat: {"description":"ANK 14","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25855297","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	116
Details	Repeat: {"description":"ANK 15","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25855297","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	120
Details	Repeat: {"description":"ANK 16","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25855297","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	116
Details	Coiled coil: {"evidences":[{"source":"PubMed","id":"25855297","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	4
Details	Binding site: {"description":"covalent; Cys highly reactive","evidences":[{"source":"UniProtKB","id":"Q8BLA8","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"17164327","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27241698","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	8
Details	Binding site: {"description":"covalent","evidences":[{"source":"PubMed","id":"17164327","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	4
Details	Binding site: {"description":"covalent","evidences":[{"source":"PubMed","id":"17164327","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27241698","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32641835","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6V9V","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25855297","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	4
Details	Site: {"description":"Required for C-621 reactivity","evidences":[{"source":"PubMed","id":"27241698","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	4
Details	Site: {"description":"Essential for electrophile activation. Sensor for electrophilic agents","evidences":[{"source":"PubMed","id":"31866091","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32641835","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	4
Details	Site: {"description":"Key residue for activation by the scorpion wasabi receptor toxin","evidences":[{"source":"PubMed","id":"31447178","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	8
Details	Site: {"description":"Important residue for activation by the scorpion wasabi receptor toxin","evidences":[{"source":"PubMed","id":"31447178","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	4
Details	Site: {"description":"Important for electrophile activation","evidences":[{"source":"PubMed","id":"31866091","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32641835","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	4
Details	Site: {"description":"Crucial for calcium permeation","evidences":[{"source":"UniProtKB","id":"Q6RI86","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	8
Details	Modified residue: {"description":"Cysteine sulfenic acid (-SOH); transient; in hyperoxia","evidences":[{"source":"PubMed","id":"21873995","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI25
Number of Residues	8
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)