7EVJ

Crystal structure of CBP bromodomain liganded with 9c

Summary for 7EVJ

• Entry DOI: 10.2210/pdb7evj/pdb
• Descriptor: CREB-binding protein, 3-acetyl-1-((3-(1-cyclopropyl-1H-pyrazol-4-yl)-2-fluoro-5-(hydroxymethyl)phenyl)carbamoyl)indolizin-7-yl dimethylcarbamate, PHOSPHATE ION, ... (5 entities in total)
• Functional Keywords: histone acetyltransferase, cbp, bromodomain, protein binding
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 16597.89

Authors

Xiang, Q.,Wang, C.,Wu, T.,Zhang, Y.,Zhang, C.,Luo, G.,Wu, X.,Shen, H.,Xu, Y. (deposition date: 2021-05-21, release date: 2022-02-16, Last modification date: 2023-11-29)

• Primary citation: Xiang, Q.,Wang, C.,Wu, T.,Zhang, C.,Hu, Q.,Luo, G.,Hu, J.,Zhuang, X.,Zou, L.,Shen, H.,Wu, X.,Zhang, Y.,Kong, X.,Liu, J.,Xu, Y.; Design, Synthesis, and Biological Evaluation of 1-(Indolizin-3-yl)ethan-1-ones as CBP Bromodomain Inhibitors for the Treatment of Prostate Cancer.; J.Med.Chem., 65:785-810, 2022; PubMed: 34962793; DOI: 10.1021/acs.jmedchem.1c01864

Experimental method

X-RAY DIFFRACTION (2.57 Å)