7EVJ

Crystal structure of CBP bromodomain liganded with 9c

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	CREB-binding protein	polymer	133	15891.3	1	UniProt (Q92793) Pfam (PF00439)	Homo sapiens (Human)
2	B (A)	3-acetyl-1-((3-(1-cyclopropyl-1H-pyrazol-4-yl)-2-fluoro-5-(hydroxymethyl)phenyl)carbamoyl)indolizin-7-yl dimethylcarbamate	non-polymer		519.5	1	Chemie (JE9)
3	C (A)	PHOSPHATE ION	non-polymer		95.0	1	Chemie (PO4)
4	D (A)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
5	E (A)	water	water		18.0	33	Chemie (HOH)

Sequence modifications

A: 1081 - 1197 (UniProt: Q92793)

PDB	External Database	Details
Met 1065	-	expression tag
Lys 1066	-	expression tag
Lys 1067	-	expression tag
Gly 1068	-	expression tag
His 1069	-	expression tag
His 1070	-	expression tag
His 1071	-	expression tag
His 1072	-	expression tag
His 1073	-	expression tag
His 1074	-	expression tag
Leu 1075	-	expression tag
Val 1076	-	expression tag
Pro 1077	-	expression tag
Arg 1078	-	expression tag
Gly 1079	-	expression tag
Ser 1080	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	15891.3
Non-Polymers*	Number of molecules	3
	Total formula weight	706.6
All*	Total formula weight	16597.9

*Water molecules are not included.