8D73

Crystal Structure of EGFR LRTM with compound 7

Summary for 8D73

Entry DOI	10.2210/pdb8d73/pdb
Descriptor	Epidermal growth factor receptor, GLYCEROL, (3S,4R)-3-fluoro-1-(4-{[4-(methylamino)-1-(propan-2-yl)pyrido[3,4-d]pyridazin-7-yl]amino}pyrimidin-2-yl)piperidin-4-ol, ... (4 entities in total)
Functional Keywords	protein kinase, inhibitor, kinase domain, mutation, signaling protein
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	80604.67
Authors	Kim, J.L. (deposition date: 2022-06-07, release date: 2022-07-27, Last modification date: 2023-10-18)
Primary citation	Eno, M.S.,Brubaker, J.D.,Campbell, J.E.,De Savi, C.,Guzi, T.J.,Williams, B.D.,Wilson, D.,Wilson, K.,Brooijmans, N.,Kim, J.,Ozen, A.,Perola, E.,Hsieh, J.,Brown, V.,Fetalvero, K.,Garner, A.,Zhang, Z.,Stevison, F.,Woessner, R.,Singh, J.,Timsit, Y.,Kinkema, C.,Medendorp, C.,Lee, C.,Albayya, F.,Zalutskaya, A.,Schalm, S.,Dineen, T.A. Discovery of BLU-945, a Reversible, Potent, and Wild-Type-Sparing Next-Generation EGFR Mutant Inhibitor for Treatment-Resistant Non-Small-Cell Lung Cancer. J.Med.Chem., 65:9662-9677, 2022 Cited by PubMed: 35838760 DOI: 10.1021/acs.jmedchem.2c00704 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.17 Å)

Structure validation