7XNE

Crystal structure of CBP bromodomain liganded with Y08284

Summary for 7XNE

• Entry DOI: 10.2210/pdb7xne/pdb
• Descriptor: CREB-binding protein, N-[3-(1-cyclopropylpyrazol-4-yl)-2-fluoranyl-5-[(1S)-1-oxidanylethyl]phenyl]-3-ethanoyl-7-methoxy-indolizine-1-carboxamide, GLYCEROL, ... (4 entities in total)
• Functional Keywords: histone acetyltransferase, protein binding
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 32827.69

Authors

Xiang, Q.,Wang, C.,Wu, T.,Zhang, C.,Hu, Q.,Luo, G.,Hu, J.,Zhuang, X.,Zou, L.,Shen, H.,Wu, X.,Zhang, Y.,Kong, X.,Xu, Y. (deposition date: 2022-04-28, release date: 2022-07-06, Last modification date: 2023-11-29)

• Primary citation: Xiang, Q.,Wang, C.,Wu, T.,Zhang, C.,Hu, Q.,Luo, G.,Hu, J.,Zhuang, X.,Zou, L.,Shen, H.,Wu, X.,Zhang, Y.,Kong, X.,Liu, J.,Xu, Y.; Design, Synthesis, and Biological Evaluation of 1-(Indolizin-3-yl)ethan-1-ones as CBP Bromodomain Inhibitors for the Treatment of Prostate Cancer.; J.Med.Chem., 65:785-810, 2022; PubMed: 34962793; DOI: 10.1021/acs.jmedchem.1c01864

Experimental method

X-RAY DIFFRACTION (2.17 Å)