7ZY6

Identification of M4205 a highly selective inhibitor of cKIT mutations for unresectable metastatic or recurrent GIST

Summary for 7ZY6

Entry DOI	10.2210/pdb7zy6/pdb
Descriptor	HUMAN PROTO-ONCOGENE C-KIT, 5-imidazo[1,2-a]pyridin-3-yl-~{N}-[(1~{R})-1-(6-pyrrolidin-1-ylpyridin-3-yl)ethyl]pyridin-3-amine (3 entities in total)
Functional Keywords	tyrosine-protein kinase, ckit, transferase
Biological source	Homo sapiens
Total number of polymer chains	1
Total formula weight	37562.43
Authors	Graedler, U.,Lammens, A. (deposition date: 2022-05-24, release date: 2023-02-22, Last modification date: 2024-02-07)
Primary citation	Blum, A.,Dorsch, D.,Linde, N.,Brandstetter, S.,Buchstaller, H.P.,Busch, M.,Glaser, N.,Gradler, U.,Ruff, A.,Petersson, C.,Schieferstein, H.,Sherbetjian, E.,Esdar, C. Identification of M4205─A Highly Selective Inhibitor of KIT Mutations for Treatment of Unresectable Metastatic or Recurrent Gastrointestinal Stromal Tumors. J.Med.Chem., 66:2386-2395, 2023 Cited by PubMed: 36728508 DOI: 10.1021/acs.jmedchem.2c00851 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.09 Å)

Structure validation