PDB: 697 resultsInfo pagesStatus searchChemie searchBIRD

---

5FXG	GLUN1B-GLUN2B NMDA RECEPTOR IN ACTIVE CONFORMATION Descriptor: N-METHYL-D-ASPARTATE RECEPTOR GLUN1, N-METHYL-D-ASPARTATE RECEPTOR GLUN2B Authors: Tajima, N, Karakas, E, Grant, T, Simorowski, N, Diaz-Avalos, R, Grigorieff, N, Furukawa, H. Deposit date: 2016-03-02 Release date: 2016-05-11 Last modified: 2024-05-08 Method: ELECTRON MICROSCOPY (6.8 Å) Cite: Activation of Nmda Receptors and the Mechanism of Inhibition by Ifenprodil. Nature, 534, 2016
5H8H	Structure of the human GluN1/GluN2A LBD in complex with GNE3419 Descriptor: 7-[[ethyl(phenyl)amino]methyl]-2-methyl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one, ACETATE ION, CALCIUM ION, ... Authors: Wallweber, H.J.A, Lupardus, P.J. Deposit date: 2015-12-23 Release date: 2016-02-24 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.23 Å) Cite: Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function. Neuron, 89, 2016
5H8F	Structure of the apo human GluN1/GluN2A LBD Descriptor: GLUTAMIC ACID, GLYCEROL, GLYCINE, ... Authors: Wallweber, H.J.A, Lupardus, P.J. Deposit date: 2015-12-23 Release date: 2016-02-24 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.81 Å) Cite: Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function. Neuron, 89, 2016
5H8S	Structure of the human GluA2 LBD in complex with GNE3419 Descriptor: 7-[[ethyl(phenyl)amino]methyl]-2-methyl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one, CACODYLATE ION, GLUTAMIC ACID, ... Authors: Wallweber, H.J.A, Lupardus, P.J. Deposit date: 2015-12-23 Release date: 2016-02-24 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.703 Å) Cite: Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function. Neuron, 89, 2016
5H8Q	Structure of the human GluN1/GluN2A LBD in complex with GNE8324 Descriptor: 6-[[ethyl-(4-fluorophenyl)amino]methyl]-2,3-dihydro-1~{H}-cyclopenta[3,4][1,3]thiazolo[1,4-~{a}]pyrimidin-8-one, ACETATE ION, GLUTAMIC ACID, ... Authors: Wallweber, H.J.A, Lupardus, P.J. Deposit date: 2015-12-23 Release date: 2016-02-24 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function. Neuron, 89, 2016
5FXH	GluN1b-GluN2B NMDA receptor in non-active-1 conformation Descriptor: N-METHYL-D-ASPARTATE RECEPTOR GLUN1, N-METHYL-D-ASPARTATE RECEPTOR GLUN2B Authors: Tajima, N, Karakas, E, Grant, T, Simorowski, N, Diaz-Avalos, R, Grigorieff, N, Furukawa, H. Deposit date: 2016-03-02 Release date: 2016-05-11 Last modified: 2024-05-08 Method: ELECTRON MICROSCOPY (5 Å) Cite: Activation of Nmda Receptors and the Mechanism of Inhibition by Ifenprodil. Nature, 534, 2016
5H8N	Structure of the human GluN1/GluN2A LBD in complex with NAM Descriptor: 4-[[(4-fluorophenyl)sulfonylamino]methyl]-~{N}-(pyridin-3-ylmethyl)benzamide, CALCIUM ION, GLUTAMIC ACID, ... Authors: Wallweber, H.J.A, Lupardus, P.J. Deposit date: 2015-12-23 Release date: 2016-02-24 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function. Neuron, 89, 2016
5I59	Glutamate- and glycine-bound GluN1/GluN2A agonist binding domains with MPX 007 Descriptor: 5-({[(3,4-difluorophenyl)sulfonyl]amino}methyl)-6-methyl-N-[(2-methyl-4H-1lambda~4~,3-thiazol-5-yl)methyl]pyrazine-2-carboxamide, GLUTAMIC ACID, GLYCINE, ... Authors: Mou, T.-C, Sprang, S.R, Hansen, K.B. Deposit date: 2016-02-14 Release date: 2016-09-21 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Structural Basis for Negative Allosteric Modulation of GluN2A-Containing NMDA Receptors. Neuron, 91, 2016
5IOU	Cryo-EM structure of GluN1/GluN2B NMDA receptor in the glutamate/glycine-bound conformation Descriptor: GLUTAMIC ACID, GLYCINE, Ionotropic glutamate receptor subunit NR2B, ... Authors: Zhu, S, Stein, A.R, Yoshioka, C, Lee, C.H, Goehring, A, Mchaourab, S.H, Gouaux, E. Deposit date: 2016-03-09 Release date: 2016-04-20 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (7 Å) Cite: Mechanism of NMDA Receptor Inhibition and Activation. Cell, 165, 2016
5IPU	Cryo-EM structure of GluN1/GluN2B NMDA receptor in the DCKA/D-APV-bound conformation, state 6 Descriptor: Ionotropic glutamate receptor subunit NR2B, N-methyl-D-aspartate receptor subunit NR1-8a Authors: Zhu, S, Stein, A.R, Yoshioka, C, Lee, C.H, Goehring, A, Mchaourab, S.H, Gouaux, E. Deposit date: 2016-03-09 Release date: 2016-04-20 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (15.4 Å) Cite: Mechanism of NMDA Receptor Inhibition and Activation. Cell, 165, 2016
5I2K	Structure of the human GluN1/GluN2A LBD in complex with 7-{[ethyl(4-fluorophenyl)amino]methyl}-N,2-dimethyl-5-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-3-carboxamide (compound 19) Descriptor: 7-{[ethyl(4-fluorophenyl)amino]methyl}-N,2-dimethyl-5-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-3-carboxamide, GLUTAMIC ACID, GLYCINE, ... Authors: Wallweber, H.J.A, Lupardus, P.J. Deposit date: 2016-02-09 Release date: 2016-03-16 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.86 Å) Cite: Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design. J.Med.Chem., 59, 2016
3PMV	Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator Descriptor: GLUTAMIC ACID, GLYCEROL, Glutamate receptor 2, ... Authors: Maclean, J.K.F, Jamieson, C, Brown, C.I, Campbell, R.A, Gillen, K.J, Gillespie, J, Kazemier, B, Kiczun, M, Lamont, Y, Lyons, A.J, Moir, E.M, Morrow, J.A, Pantling, J, Rankovic, Z, Smith, L. Deposit date: 2010-11-18 Release date: 2011-01-12 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structure based evolution of a novel series of positive modulators of the AMPA receptor. Bioorg.Med.Chem.Lett., 21, 2011
3QXM	Crystal Structure of Human GluK2 Ligand-Binding Core in Complex with Novel Marine-Derived Toxins, Neodysiherbaine A Descriptor: (2R,3aR,6R,7R,7aR)-2-[(2S)-2-amino-2-carboxyethyl]-6,7-dihydroxyhexahydro-2H-furo[3,2-b]pyran-2-carboxylic acid, Glutamate receptor ionotropic, kainate 2 Authors: Unno, M, Sasaki, M, Ikeda-Saito, M. Deposit date: 2011-03-02 Release date: 2011-10-26 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Binding and Selectivity of the Marine Toxin Neodysiherbaine A and Its Synthetic Analogues to GluK1 and GluK2 Kainate Receptors. J.Mol.Biol., 413, 2011
3PMW	Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator Descriptor: DIMETHYL SULFOXIDE, GLUTAMIC ACID, GLYCEROL, ... Authors: Maclean, J.K.F, Jamieson, C, Brown, C.I, Campbell, R.A, Gillen, K.J, Gillespie, J, Kazemier, B, Kiczun, M, Lamont, Y, Lyons, A.J, Moir, E.M, Morrow, J.A, Pantling, J, Rankovic, Z, Smith, L. Deposit date: 2010-11-18 Release date: 2011-01-12 Last modified: 2023-05-31 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structure based evolution of a novel series of positive modulators of the AMPA receptor. Bioorg.Med.Chem.Lett., 21, 2011
3PMX	Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator Descriptor: 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, GLUTAMIC ACID, ... Authors: Maclean, J.K.F, Jamieson, C, Brown, C.I, Campbell, R.A, Gillen, K.J, Gillespie, J, Kazemier, B, Kiczun, M, Lamont, Y, Lyons, A.J, Moir, E.M, Morrow, J.A, Pantling, J, Rankovic, Z, Smith, L. Deposit date: 2010-11-18 Release date: 2011-01-12 Last modified: 2017-08-09 Method: X-RAY DIFFRACTION (1.87 Å) Cite: Structure based evolution of a novel series of positive modulators of the AMPA receptor. Bioorg.Med.Chem.Lett., 21, 2011
3O6H	Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator Descriptor: 1,2-ETHANEDIOL, 2-[({4-[(ethylamino)methyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl}acetyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, DIMETHYL SULFOXIDE, ... Authors: Maclean, J.K.F, Campbell, R.A, Cumming, I.A, Gillen, K.J, Gillespie, J, Jamieson, C, Kazemier, B, Kiczun, M, Lamont, Y, Lyons, A.J, Martin, F, Moir, E.M, Morrow, J.A, Pantling, J, Rankovic, Z, Smith, L. Deposit date: 2010-07-29 Release date: 2010-09-15 Last modified: 2017-08-09 Method: X-RAY DIFFRACTION (2.1 Å) Cite: A novel series of positive modulators of the AMPA receptor: structure-based lead optimization. Bioorg.Med.Chem.Lett., 20, 2010
3RN8	Crystal Structure of iGluR2 Ligand Binding Domain and Symmetrical Carboxyl Containing Potentiator Descriptor: 3,3'-benzene-1,4-diylbis(4-cyano-5-ethylthiophene-2-carboxylic acid), ACETATE ION, GLUTAMIC ACID, ... Authors: Timm, D.E. Deposit date: 2011-04-22 Release date: 2011-05-25 Last modified: 2017-08-23 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structural and functional analysis of two new positive allosteric modulators of GluA2 desensitization and deactivation. Mol.Pharmacol., 80, 2011
3R7X	Crystal Structure Analysis of a Quinazolinedione sulfonamide bound to human GluR2: A Novel Class of Competitive AMPA Receptor Antagonists with Oral Activity Descriptor: GLUTAMIC ACID, Glutamate receptor 2, N-[6-(1H-imidazol-1-yl)-7-nitro-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl]methanesulfonamide Authors: Kallen, J. Deposit date: 2011-03-23 Release date: 2011-05-18 Last modified: 2017-07-26 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Quinazolinedione sulfonamides: A novel class of competitive AMPA receptor antagonists with oral activity. Bioorg.Med.Chem.Lett., 21, 2011
3RTF	Chlorowillardiine bound to the ligand binding domain of GluA2 Descriptor: 3-(5-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine, Glutamate receptor 2, ZINC ION Authors: Ahmed, A.H, Oswald, R.E. Deposit date: 2011-05-03 Release date: 2011-05-18 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Mechanisms of Modal Activation of GluA3 Receptors. Mol.Pharmacol., 80, 2011
3RNN	Crystal Structure of iGluR2 Ligand Binding Domain with Symmetric Sulfonamide Containing Potentiator Descriptor: GLUTAMIC ACID, Glutamate receptor 2, N,N'-(benzene-1,4-diyldiethane-2,1-diyl)dipropane-2-sulfonamide, ... Authors: Timm, D.E. Deposit date: 2011-04-22 Release date: 2011-05-25 Last modified: 2019-07-17 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Structural and functional analysis of two new positive allosteric modulators of GluA2 desensitization and deactivation. Mol.Pharmacol., 80, 2011
3O6G	Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator Descriptor: 1,2-ETHANEDIOL, GLUTAMIC ACID, Glutamate receptor 2, ... Authors: Maclean, J.K.F, Campbell, R.A, Cumming, I.A, Gillen, K.J, Gillespie, J, Jamieson, C, Kazemier, B, Kiczun, M, Lamont, Y, Lyons, A.J, Martin, F, Moir, E.M, Morrow, J.A, Pantling, J, Rankovic, Z, Smith, L. Deposit date: 2010-07-29 Release date: 2010-09-15 Last modified: 2017-08-09 Method: X-RAY DIFFRACTION (1.8 Å) Cite: A novel series of positive modulators of the AMPA receptor: structure-based lead optimization. Bioorg.Med.Chem.Lett., 20, 2010
3OEL	Crystal structure of GluN2D ligand-binding core in complex with D-glutamate Descriptor: D-GLUTAMIC ACID, Glutamate [NMDA] receptor subunit epsilon-4 Authors: Simorowski, N, Furukawa, H. Deposit date: 2010-08-12 Release date: 2011-05-11 Last modified: 2017-08-23 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors. Nat Commun, 2, 2011
3RT6	Fluorowillardiine bound to the ligand binding domain of GluA3 Descriptor: 2-AMINO-3-(5-FLUORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID, Glutamate receptor 3, ZINC ION Authors: Ahmed, A.H, Oswald, R.E. Deposit date: 2011-05-03 Release date: 2011-05-18 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.836 Å) Cite: Mechanisms of Modal Activation of GluA3 Receptors. Mol.Pharmacol., 80, 2011
3RT8	Chlorowillardiine bound to the ligand binding domain of GluA3 Descriptor: 3-(5-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine, Glutamate receptor 3, ZINC ION Authors: Ahmed, A.H, Oswald, R.E. Deposit date: 2011-05-03 Release date: 2011-05-18 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.426 Å) Cite: Mechanisms of Modal Activation of GluA3 Receptors. Mol.Pharmacol., 80, 2011
3PD8	X-ray structure of the ligand-binding core of GluA2 in complex with (S)-7-HPCA at 2.5 A resolution Descriptor: (7S)-3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-7-carboxylic acid, ACETIC ACID, CACODYLATE ION, ... Authors: Frydenvang, K, Kastrup, J.S. Deposit date: 2010-10-22 Release date: 2010-12-29 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.476 Å) Cite: Biostructural and pharmacological studies of bicyclic analogues of the 3-isoxazolol glutamate receptor agonist ibotenic acid. J. Med. Chem., 53, 2010

<12131415161718192021222324252627>