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PDB: 94 results
1PB7
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BU of 1pb7 by Molmil
CRYSTAL STRUCTURE OF THE NR1 LIGAND BINDING CORE IN COMPLEX WITH GLYCINE AT 1.35 ANGSTROMS RESOLUTION
Descriptor: GLYCINE, N-methyl-D-aspartate Receptor Subunit 1
Authors:Furukawa, H, Gouaux, E.
Deposit date:2003-05-14
Release date:2003-06-24
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core
Embo J., 22, 2003
1PB8
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BU of 1pb8 by Molmil
CRYSTAL STRUCTURE OF THE NR1 LIGAND BINDING CORE IN COMPLEX WITH D-SERINE AT 1.45 ANGSTROMS RESOLUTION
Descriptor: D-SERINE, N-methyl-D-aspartate Receptor Subunit 1
Authors:Furukawa, H, Gouaux, E.
Deposit date:2003-05-14
Release date:2003-06-24
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core
Embo J., 22, 2003
1PB9
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BU of 1pb9 by Molmil
CRYSTAL STRUCTURE OF THE NR1 LIGAND BINDING CORE IN COMPLEX WITH D-CYCLOSERINE AT 1.60 ANGSTROMS RESOLUTION
Descriptor: (R)-4-AMINO-ISOXAZOLIDIN-3-ONE, N-methyl-D-aspartate Receptor Subunit 1
Authors:Furukawa, H, Gouaux, E.
Deposit date:2003-05-14
Release date:2003-06-24
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core
Embo J., 22, 2003
1PBQ
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BU of 1pbq by Molmil
CRYSTAL STRUCTURE OF THE NR1 LIGAND BINDING CORE IN COMPLEX WITH 5,7-DICHLOROKYNURENIC ACID (DCKA) AT 1.90 ANGSTROMS RESOLUTION
Descriptor: 5,7-DICHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID, N-methyl-D-aspartate Receptor Subunit 1
Authors:Furukawa, H, Gouaux, E.
Deposit date:2003-05-14
Release date:2003-07-29
Last modified:2020-07-15
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core
Embo J., 22, 2003
2A5S
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BU of 2a5s by Molmil
Crystal Structure Of The NR2A Ligand Binding Core In Complex With Glutamate
Descriptor: GLUTAMIC ACID, N-methyl-D-aspartate receptor NMDAR2A subunit
Authors:Furukawa, H, Singh, S.K, Mancusso, R, Gouaux, E.
Deposit date:2005-06-30
Release date:2005-11-15
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Subunit arrangement and function in NMDA receptors
Nature, 438, 2005
2A5T
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BU of 2a5t by Molmil
Crystal Structure Of The NR1/NR2A ligand-binding cores complex
Descriptor: GLUTAMIC ACID, GLYCINE, N-methyl-D-aspartate receptor NMDAR1-4a subunit, ...
Authors:Furukawa, H, Singh, S.K, Mancusso, R, Gouaux, E.
Deposit date:2005-06-30
Release date:2005-11-15
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2 Å)
Cite:Subunit arrangement and function in NMDA receptors
Nature, 438, 2005
6CNA
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BU of 6cna by Molmil
GluN1-GluN2B NMDA receptors with exon 5
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ...
Authors:Furukawa, H, Grant, T, Grigorieff, N.
Deposit date:2018-03-07
Release date:2018-10-03
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:Structural Mechanism of Functional Modulation by Gene Splicing in NMDA Receptors.
Neuron, 98, 2018
8USX
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BU of 8usx by Molmil
Glycine-bound GluN1a-3A NMDA receptor
Descriptor: Glutamate receptor ionotropic, NMDA 1, NMDA 3A
Authors:Michalski, K, Furukawa, H.
Deposit date:2023-10-30
Release date:2024-04-17
Last modified:2024-04-24
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structure and function of GluN1-3A NMDA receptor excitatory glycine receptor channel.
Sci Adv, 10, 2024
8UUE
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BU of 8uue by Molmil
Glycine-bound GluN1a-3A LBD heterotetramer (local refinement)
Descriptor: Glutamate receptor ionotropic, NMDA 1, NMDA 3A
Authors:Michalski, K, Furukawa, H.
Deposit date:2023-11-01
Release date:2024-04-17
Last modified:2024-04-24
Method:ELECTRON MICROSCOPY (3.96 Å)
Cite:Structure and function of GluN1-3A NMDA receptor excitatory glycine receptor channel.
Sci Adv, 10, 2024
8USW
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BU of 8usw by Molmil
CNQX-bound GluN1a-3A NMDA receptor
Descriptor: 7-nitro-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-carbonitrile, Glutamate receptor ionotropic, NMDA 1, ...
Authors:Michalski, K, Furukawa, H.
Deposit date:2023-10-30
Release date:2024-04-17
Last modified:2024-04-24
Method:ELECTRON MICROSCOPY (4.23 Å)
Cite:Structure and function of GluN1-3A NMDA receptor excitatory glycine receptor channel.
Sci Adv, 10, 2024
8E96
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BU of 8e96 by Molmil
Glycine and glutamate bound Human GluN1a-GluN2D NMDA receptor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMIC ACID, GLYCINE, ...
Authors:Kang, H, Furukawa, H.
Deposit date:2022-08-26
Release date:2022-12-07
Last modified:2022-12-14
Method:ELECTRON MICROSCOPY (3.38 Å)
Cite:Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs.
Mol.Cell, 82, 2022
8E99
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BU of 8e99 by Molmil
Human GluN1a-GluN2A-GluN2C triheteromeric NMDA receptor in complex with Nb-4
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ...
Authors:Chou, T.-H, Furukawa, H.
Deposit date:2022-08-26
Release date:2022-12-07
Last modified:2022-12-14
Method:ELECTRON MICROSCOPY (4.24 Å)
Cite:Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs.
Mol.Cell, 82, 2022
8E97
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BU of 8e97 by Molmil
PYD-106-bound Human GluN1a-GluN2C NMDA receptor in splayed conformation
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ...
Authors:Chou, T.-H, Furukawa, H.
Deposit date:2022-08-26
Release date:2022-12-07
Last modified:2022-12-14
Method:ELECTRON MICROSCOPY (4.19 Å)
Cite:Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs.
Mol.Cell, 82, 2022
8E94
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BU of 8e94 by Molmil
PYD-106-bound Human GluN1a-GluN2C NMDA receptor in intact conformation
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Chou, T.-H, Furukawa, H.
Deposit date:2022-08-26
Release date:2022-12-07
Last modified:2022-12-14
Method:ELECTRON MICROSCOPY (3.72 Å)
Cite:Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs.
Mol.Cell, 82, 2022
8E98
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BU of 8e98 by Molmil
D-cycloserine and glutamate bound Human GluN1a-GluN2C NMDA receptor in nanodisc - intact conformation
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, NMDA 1, ...
Authors:Chou, T.-H, Furukawa, H.
Deposit date:2022-08-26
Release date:2022-12-07
Last modified:2022-12-14
Method:ELECTRON MICROSCOPY (3.75 Å)
Cite:Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs.
Mol.Cell, 82, 2022
8E92
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BU of 8e92 by Molmil
D-cycloserine and glutamate bound Human GluN1a-GluN2C NMDA receptor in intact conformation
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ...
Authors:Chou, T.-H, Furukawa, H.
Deposit date:2022-08-26
Release date:2022-12-07
Last modified:2022-12-14
Method:ELECTRON MICROSCOPY (3.96 Å)
Cite:Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs.
Mol.Cell, 82, 2022
8E93
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BU of 8e93 by Molmil
D-cycloserine and glutamate bound Human GluN1a-GluN2C NMDA receptor in splayed conformation
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ...
Authors:Chou, T.-H, Furukawa, H.
Deposit date:2022-08-26
Release date:2022-12-07
Last modified:2022-12-14
Method:ELECTRON MICROSCOPY (3.71 Å)
Cite:Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs.
Mol.Cell, 82, 2022
8S8Z
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BU of 8s8z by Molmil
Cryo-EM structure of octameric human CALHM1 (I109W) in complex with ruthenium red
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Calcium homeostasis modulator protein 1, ruthenium(6+) azanide pentaamino(oxido)ruthenium (1/4/2)
Authors:Syrjanen, J.L, Furukawa, H.
Deposit date:2023-03-27
Release date:2023-07-26
Method:ELECTRON MICROSCOPY (3.91 Å)
Cite:Structure of human CALHM1 reveals key locations for channel regulation and blockade by ruthenium red
Nat Commun, 14, 2023
8S90
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BU of 8s90 by Molmil
Cryo-EM structure of octameric human CALHM1 (I109W) in complex with ruthenium red (C1)
Descriptor: Calcium homeostasis modulator protein 1, ruthenium(6+) azanide pentaamino(oxido)ruthenium (1/4/2)
Authors:Syrjanen, J.L, Furukawa, H.
Deposit date:2023-03-27
Release date:2023-07-26
Method:ELECTRON MICROSCOPY (4.73 Å)
Cite:Structure of human CALHM1 reveals key locations for channel regulation and blockade by ruthenium red
Nat Commun, 14, 2023
2QTS
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BU of 2qts by Molmil
Structure of an acid-sensing ion channel 1 at 1.9 A resolution and low pH
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Acid-sensing ion channel, CHLORIDE ION, ...
Authors:Jasti, J, Furukawa, H, Gonzales, E.B, Gouaux, E.
Deposit date:2007-08-02
Release date:2007-09-25
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of acid-sensing ion channel 1 at 1.9A resolution and low pH
Nature, 449, 2007
7SAC
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BU of 7sac by Molmil
S-(+)-ketamine bound GluN1a-GluN2B NMDA receptors at 3.69 Angstrom resolution
Descriptor: (2~{S})-2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Chou, T.-H, Furukawa, H.
Deposit date:2021-09-22
Release date:2022-07-20
Last modified:2022-10-26
Method:ELECTRON MICROSCOPY (3.69 Å)
Cite:Structural insights into binding of therapeutic channel blockers in NMDA receptors.
Nat.Struct.Mol.Biol., 29, 2022
7SAA
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BU of 7saa by Molmil
Glycine and glutamate bound GluN1a-GluN2B NMDA receptors in non-active 1 conformation at 2.97 Angstrom resolution
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMIC ACID, ...
Authors:Chou, T.-H, Furukawa, H.
Deposit date:2021-09-22
Release date:2022-07-20
Method:ELECTRON MICROSCOPY (2.97 Å)
Cite:Structural insights into binding of therapeutic channel blockers in NMDA receptors.
Nat.Struct.Mol.Biol., 29, 2022
7SAD
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BU of 7sad by Molmil
Memantine-bound GluN1a-GluN2B NMDA receptors
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ...
Authors:Chou, T.-H, Furukawa, H.
Deposit date:2021-09-22
Release date:2022-07-20
Method:ELECTRON MICROSCOPY (3.96 Å)
Cite:Structural insights into binding of therapeutic channel blockers in NMDA receptors.
Nat.Struct.Mol.Biol., 29, 2022
7SAB
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BU of 7sab by Molmil
Phencyclidine-bound GluN1a-GluN2B NMDA receptors
Descriptor: 1-(PHENYL-1-CYCLOHEXYL)PIPERIDINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Chou, T.-H, Furukawa, H.
Deposit date:2021-09-22
Release date:2022-07-20
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structural insights into binding of therapeutic channel blockers in NMDA receptors.
Nat.Struct.Mol.Biol., 29, 2022
8G18
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Heterodimer of the GluN1b-GluN2B NMDA receptor amino-terminal domains bound to allosteric inhibitor 93-108
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, NMDA 1, ...
Authors:Regan, M.C, Furukawa, H.
Deposit date:2023-02-01
Release date:2023-03-01
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Novel GluN2B-Selective NMDA Receptor Negative Allosteric Modulator Possesses Intrinsic Analgesic Properties and Enhances Analgesia of Morphine in a Rodent Tail Flick Pain Model.
Acs Chem Neurosci, 14, 2023

 

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