8G18
Heterodimer of the GluN1b-GluN2B NMDA receptor amino-terminal domains bound to allosteric inhibitor 93-108
Summary for 8G18
Entry DOI | 10.2210/pdb8g18/pdb |
Descriptor | Glutamate receptor ionotropic, NMDA 1, Glutamate receptor ionotropic, NMDA 2B, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total) |
Functional Keywords | nmdar, amino-terminal domain, allosteric inhibitor, membrane protein, membrane protein-inhibitor complex, membrane protein/inhibitor |
Biological source | Xenopus laevis (African clawed frog) More |
Total number of polymer chains | 4 |
Total formula weight | 170548.91 |
Authors | Regan, M.C.,Furukawa, H. (deposition date: 2023-02-01, release date: 2023-03-01, Last modification date: 2023-10-25) |
Primary citation | Harris, L.D.,Regan, M.C.,Myers, S.J.,Nocilla, K.A.,Akins, N.S.,Tahirovic, Y.A.,Wilson, L.J.,Dingledine, R.,Furukawa, H.,Traynelis, S.F.,Liotta, D.C. Novel GluN2B-Selective NMDA Receptor Negative Allosteric Modulator Possesses Intrinsic Analgesic Properties and Enhances Analgesia of Morphine in a Rodent Tail Flick Pain Model. Acs Chem Neurosci, 14:917-935, 2023 Cited by PubMed: 36779874DOI: 10.1021/acschemneuro.2c00779 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.85 Å) |
Structure validation
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