8G18

Heterodimer of the GluN1b-GluN2B NMDA receptor amino-terminal domains bound to allosteric inhibitor 93-108

Summary for 8G18

• Entry DOI: 10.2210/pdb8g18/pdb
• Descriptor: Glutamate receptor ionotropic, NMDA 1, Glutamate receptor ionotropic, NMDA 2B, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: nmdar, amino-terminal domain, allosteric inhibitor, membrane protein, membrane protein-inhibitor complex, membrane protein/inhibitor
• Biological source: Xenopus laevis (African clawed frog); More
• Total number of polymer chains: 4
• Total formula weight: 170548.91

Authors

Regan, M.C.,Furukawa, H. (deposition date: 2023-02-01, release date: 2023-03-01, Last modification date: 2023-10-25)

• Primary citation: Harris, L.D.,Regan, M.C.,Myers, S.J.,Nocilla, K.A.,Akins, N.S.,Tahirovic, Y.A.,Wilson, L.J.,Dingledine, R.,Furukawa, H.,Traynelis, S.F.,Liotta, D.C.; Novel GluN2B-Selective NMDA Receptor Negative Allosteric Modulator Possesses Intrinsic Analgesic Properties and Enhances Analgesia of Morphine in a Rodent Tail Flick Pain Model.; Acs Chem Neurosci, 14:917-935, 2023; PubMed: 36779874; DOI: 10.1021/acschemneuro.2c00779

Experimental method

X-RAY DIFFRACTION (2.85 Å)