8G18
Heterodimer of the GluN1b-GluN2B NMDA receptor amino-terminal domains bound to allosteric inhibitor 93-108
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Glutamate receptor ionotropic, NMDA 1 | polymer | 385 | 42301.5 | 2 | UniProt (A0A1L8F5J9) Pfam (PF01094) UniProt (by SIFTS) (A0A8J0TPH2) | Xenopus laevis (African clawed frog) | GluN1,N-methyl-D-aspartate receptor subunit NR1,NMD-R1 |
| 2 | B, D (B, D) | Glutamate receptor ionotropic, NMDA 2B | polymer | 363 | 41280.8 | 2 | UniProt (Q00960) Pfam (PF01094) | Rattus norvegicus (rat) | GluN2B,Glutamate [NMDA] receptor subunit epsilon-2,N-methyl D-aspartate receptor subtype 2B,NMDAR2B,NR2B |
| 3 | E (E) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G22768VO) | |||
| 4 | F, H, I, K, L... (A, B, C, D) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 7 | Chemie (NAG) | |||
| 5 | G, M (A, C) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 6 | J, P (B, D) | N-(4-{3-[4-(3,4-difluorophenyl)piperazin-1-yl]-2-oxopropoxy}phenyl)methanesulfonamide | non-polymer | 439.5 | 2 | Chemie (YGW) | |||
| 7 | Q, R, S, T (A, B, C, D) | water | water | 18.0 | 94 | Chemie (HOH) |
Sequence modifications
A, C: 23 - 185 (UniProt: A0A1L8F5J9)
A, C: 211 - 407 (UniProt: A0A1L8F5J9)
B, D: 32 - 394 (UniProt: Q00960)
| PDB | External Database | Details |
|---|---|---|
| Gln 61 | Asn 61 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Gly 186 | - | linker |
| Unk 187 | - | linker |
| Unk 188 | - | linker |
| Unk 189 | - | linker |
| Unk 190 | - | linker |
| Unk 191 | - | linker |
| Unk 192 | - | linker |
| Unk 193 | - | linker |
| Unk 194 | - | linker |
| Unk 195 | - | linker |
| Unk 196 | - | linker |
| Unk 197 | - | linker |
| Unk 198 | - | linker |
| Unk 199 | - | linker |
| Unk 200 | - | linker |
| Unk 201 | - | linker |
| Unk 202 | - | linker |
| Unk 203 | - | linker |
| Unk 204 | - | linker |
| Unk 205 | - | linker |
| Unk 206 | - | linker |
| Unk 207 | - | linker |
| Unk 208 | - | linker |
| Gly 209 | - | linker |
| Pro 210 | - | linker |
| Gln 371 | Asn 350 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Asp 348 | Asn 348 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 167164.7 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 910.8 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 2473.4 | |
| All* | Total formula weight | 170548.9 |
