8G18
Heterodimer of the GluN1b-GluN2B NMDA receptor amino-terminal domains bound to allosteric inhibitor 93-108
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | Glutamate receptor ionotropic, NMDA 1 | polymer | 385 | 42301.5 | 2 | UniProt (A0A1L8F5J9) Pfam (PF01094) UniProt (by SIFTS) (A0A8J0TPH2) In PDB | Xenopus laevis (African clawed frog) | GluN1,N-methyl-D-aspartate receptor subunit NR1,NMD-R1 |
2 | B, D | Glutamate receptor ionotropic, NMDA 2B | polymer | 363 | 41280.8 | 2 | UniProt (Q00960) Pfam (PF01094) In PDB | Rattus norvegicus (rat) | GluN2B,Glutamate [NMDA] receptor subunit epsilon-2,N-methyl D-aspartate receptor subtype 2B,NMDAR2B,NR2B |
3 | E | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G22768VO) | |||
4 | A, B, C, D | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 7 | Chemie (NAG) | |||
5 | A, C | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
6 | B, D | N-(4-{3-[4-(3,4-difluorophenyl)piperazin-1-yl]-2-oxopropoxy}phenyl)methanesulfonamide | non-polymer | 439.5 | 2 | Chemie (YGW) | |||
7 | water | water | 18.0 | 94 | Chemie (HOH) |
Sequence modifications
A, C: 23 - 185 (UniProt: A0A1L8F5J9)
A, C: 211 - 407 (UniProt: A0A1L8F5J9)
B, D: 32 - 394 (UniProt: Q00960)
PDB | External Database | Details |
---|---|---|
Gln 61 | Asn 61 | conflict |
PDB | External Database | Details |
---|---|---|
Gly 186 | - | linker |
Unk 187 | - | linker |
Unk 188 | - | linker |
Unk 189 | - | linker |
Unk 190 | - | linker |
Unk 191 | - | linker |
Unk 192 | - | linker |
Unk 193 | - | linker |
Unk 194 | - | linker |
Unk 195 | - | linker |
Unk 196 | - | linker |
Unk 197 | - | linker |
Unk 198 | - | linker |
Unk 199 | - | linker |
Unk 200 | - | linker |
Unk 201 | - | linker |
Unk 202 | - | linker |
Unk 203 | - | linker |
Unk 204 | - | linker |
Unk 205 | - | linker |
Unk 206 | - | linker |
Unk 207 | - | linker |
Unk 208 | - | linker |
Gly 209 | - | linker |
Pro 210 | - | linker |
Gln 371 | Asn 350 | conflict |
PDB | External Database | Details |
---|---|---|
Asp 348 | Asn 348 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 167164.7 | |
Branched | Number of molecules | 1 |
Total formula weight | 910.8 | |
Non-Polymers* | Number of molecules | 11 |
Total formula weight | 2473.4 | |
All* | Total formula weight | 170548.9 |