8E98

D-cycloserine and glutamate bound Human GluN1a-GluN2C NMDA receptor in nanodisc - intact conformation

Summary for 8E98

Entry DOI	10.2210/pdb8e98/pdb
EMDB information	27953 27954 27955 27957 27958 27959 27960 27961
Descriptor	Glutamate receptor ionotropic, NMDA 1, Glutamate receptor ionotropic, NMDA 2C, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
Functional Keywords	ligand-gated ion channel, ionotropic glutamate receptor, synaptic protein, voltage-gate ion channel, transport protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	387830.69
Authors	Chou, T.-H.,Furukawa, H. (deposition date: 2022-08-26, release date: 2022-12-07, Last modification date: 2022-12-14)
Primary citation	Chou, T.H.,Kang, H.,Simorowski, N.,Traynelis, S.F.,Furukawa, H. Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs. Mol.Cell, 82:4548-, 2022 Cited by PubMed: 36309015 DOI: 10.1016/j.molcel.2022.10.008 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.75 Å)

Structure validation