8S8Z

Cryo-EM structure of octameric human CALHM1 (I109W) in complex with ruthenium red

Summary for 8S8Z

• Entry DOI: 10.2210/pdb8s8z/pdb
• EMDB information: 40232
• Descriptor: Calcium homeostasis modulator protein 1, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ruthenium(6+) azanide pentaamino(oxido)ruthenium (1/4/2) (3 entities in total)
• Functional Keywords: taste, assembly, calcium homeostasis modulator protein, membrane protein, channel, lipid binding, large-pore channel, ruthenium red
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 8
• Total formula weight: 285380.45

Authors

Syrjanen, J.L.,Furukawa, H. (deposition date: 2023-03-27, release date: 2023-07-26)

• Primary citation: Syrjanen, J.L.,Epstein, M.,Gomez, R.,Furukawa, H.; Structure of human CALHM1 reveals key locations for channel regulation and blockade by ruthenium red; Nat Commun, 14:3821-, 2023; DOI: 10.1038/s41467-023-39388-3

Experimental method

ELECTRON MICROSCOPY (3.91 Å)