5H8S

Structure of the human GluA2 LBD in complex with GNE3419

Summary for 5H8S

• Entry DOI: 10.2210/pdb5h8s/pdb
• Related: 5H8F 5H8H 5H8N 5H8Q 5H8R
• Descriptor: Glutamate receptor 2,Glutamate receptor 2, GLUTAMIC ACID, 7-[[ethyl(phenyl)amino]methyl]-2-methyl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one, ... (6 entities in total)
• Functional Keywords: glun1, glun2a, nmda, receptor, transport protein
• Biological source: Homo sapiens (Human); More
• Cellular location: Cell membrane ; Multi-pass membrane protein : P42262
• Total number of polymer chains: 3
• Total formula weight: 89203.57

Authors

Wallweber, H.J.A.,Lupardus, P.J. (deposition date: 2015-12-23, release date: 2016-02-24, Last modification date: 2023-09-27)

• Primary citation: Hackos, D.H.,Lupardus, P.J.,Grand, T.,Chen, Y.,Wang, T.M.,Reynen, P.,Gustafson, A.,Wallweber, H.J.,Volgraf, M.,Sellers, B.D.,Schwarz, J.B.,Paoletti, P.,Sheng, M.,Zhou, Q.,Hanson, J.E.; Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function.; Neuron, 89:983-999, 2016; PubMed: 26875626; DOI: 10.1016/j.neuron.2016.01.016

Experimental method

X-RAY DIFFRACTION (1.703 Å)