5H8S
Structure of the human GluA2 LBD in complex with GNE3419
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C, B | Glutamate receptor 2,Glutamate receptor 2 | polymer | 263 | 29210.7 | 3 | UniProt (P42262) Pfam (PF10613) Pfam (PF00060) In PDB | Homo sapiens (Human) | GluR-2, AMPA-selective glutamate receptor 2, GluR-B, GluR-K2, Glutamate receptor ionotropic, AMPA 2, GluA2 |
2 | A, C, B | GLUTAMIC ACID | non-polymer | 147.1 | 3 | Chemie (GLU) | |||
3 | A, C | 7-[[ethyl(phenyl)amino]methyl]-2-methyl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one | non-polymer | 300.4 | 2 | Chemie (5YC) | |||
4 | A, C, B | ZINC ION | non-polymer | 65.4 | 6 | Chemie (ZN) | |||
5 | A | CACODYLATE ION | non-polymer | 137.0 | 1 | Chemie (CAC) | |||
6 | water | water | 18.0 | 666 | Chemie (HOH) |
Sequence modifications
A, C, B: 3 - 117 (UniProt: P42262)
A, C, B: 120 - 263 (UniProt: P42262)
PDB | External Database | Details |
---|---|---|
Gly 1 | - | expression tag |
Ser 2 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly 118 | - | linker |
Thr 119 | - | linker |
Gly 231 | Arg 764 | engineered mutation |
Ser 242 | Asn 775 | variant |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 87632.0 | |
Non-Polymers* | Number of molecules | 12 |
Total formula weight | 1571.6 | |
All* | Total formula weight | 89203.6 |