5I2K
Structure of the human GluN1/GluN2A LBD in complex with 7-{[ethyl(4-fluorophenyl)amino]methyl}-N,2-dimethyl-5-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-3-carboxamide (compound 19)
Summary for 5I2K
Entry DOI | 10.2210/pdb5i2k/pdb |
Related | 5I2J 5I2N |
Descriptor | Glutamate receptor ionotropic, NMDA 2A, Glutamate receptor ionotropic, NMDA 1, GLUTAMIC ACID, ... (6 entities in total) |
Functional Keywords | glun1, glun2a, receptor, nmda, transport protein |
Biological source | Homo sapiens (Human) More |
Cellular location | Cell membrane; Multi-pass membrane protein: Q12879 Q05586 |
Total number of polymer chains | 2 |
Total formula weight | 65889.14 |
Authors | Wallweber, H.J.A.,Lupardus, P.J. (deposition date: 2016-02-09, release date: 2016-03-16, Last modification date: 2023-09-27) |
Primary citation | Volgraf, M.,Sellers, B.D.,Jiang, Y.,Wu, G.,Ly, C.Q.,Villemure, E.,Pastor, R.M.,Yuen, P.W.,Lu, A.,Luo, X.,Liu, M.,Zhang, S.,Sun, L.,Fu, Y.,Lupardus, P.J.,Wallweber, H.J.,Liederer, B.M.,Deshmukh, G.,Plise, E.,Tay, S.,Reynen, P.,Herrington, J.,Gustafson, A.,Liu, Y.,Dirksen, A.,Dietz, M.G.,Liu, Y.,Wang, T.M.,Hanson, J.E.,Hackos, D.,Scearce-Levie, K.,Schwarz, J.B. Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design. J.Med.Chem., 59:2760-2779, 2016 Cited by PubMed: 26919761DOI: 10.1021/acs.jmedchem.5b02010 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.86 Å) |
Structure validation
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