5I2K

Structure of the human GluN1/GluN2A LBD in complex with 7-{[ethyl(4-fluorophenyl)amino]methyl}-N,2-dimethyl-5-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-3-carboxamide (compound 19)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue GLU A 301

Chain	Residue
A	HIS87
A	ASP214
A	HOH403
A	SER113
A	LEU114
A	THR115
A	ARG120
A	GLY171
A	SER172
A	THR173
A	TYR213

---

site_id	AC2
Number of Residues	8
Details	binding site for residue GLY B 301

Chain	Residue
B	PHE93
B	PRO125
B	LEU126
B	THR127
B	ARG132
B	SER180
B	SER181
B	ASP225

---

site_id	AC3
Number of Residues	14
Details	binding site for residue 67H B 302

Chain	Residue
A	ILE116
A	PRO129
A	PHE130
A	VAL131
A	GLU132
A	THR242
A	GLY243
A	LEU263
B	LYS140
B	PRO141
B	TYR144
B	LEU270
B	HIS273
B	HOH422

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26875626","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26919761","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28105280","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5H8F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H8H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H8N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H8Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I2K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I2N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KCJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KDT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TP9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TPA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26875626","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26919761","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28105280","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5H8F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H8H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H8N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H8Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I2K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I2N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KCJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KDT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TP9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	5
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"34186027","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7EOQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EOR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EOT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EOU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26875626","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26919761","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28105280","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36959261","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5H8F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H8H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H8N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H8Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I2K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I2N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KCJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KDT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TP9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TPA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7YFF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26875626","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26919761","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28105280","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36309015","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36959261","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E96","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"5H8F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H8H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H8N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H8Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I2K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I2N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KCJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KDT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TP9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TPA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7YFR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26875626","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26919761","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28105280","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36309015","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36959261","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E96","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"5H8F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H8H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H8N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H8Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I2K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I2N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KCJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KDT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TP9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TPA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7YFF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"34186027","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36309015","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36959261","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E93","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"8E94","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"8E97","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"8E98","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"7EOQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7YFR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"34186027","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36309015","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E92","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"8E93","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"8E94","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"8E96","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"8E97","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"8E98","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"8E99","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"7EOQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---