3PMX

Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator

Summary for 3PMX

Entry DOI	10.2210/pdb3pmx/pdb
Related	3O28 3O29 3O2A 3O6G 3O6H 3O6I 3PMV 3PMW
Descriptor	Glutamate receptor 2, GLUTAMIC ACID, SULFATE ION, ... (8 entities in total)
Functional Keywords	transport protein, membrane protein, fusion protein, chimera protein
Biological source	Rattus norvegicus (rat) More
Cellular location	Cell membrane; Multi-pass membrane protein: P19491
Total number of polymer chains	1
Total formula weight	30685.19
Authors	Maclean, J.K.F.,Jamieson, C.,Brown, C.I.,Campbell, R.A.,Gillen, K.J.,Gillespie, J.,Kazemier, B.,Kiczun, M.,Lamont, Y.,Lyons, A.J.,Moir, E.M.,Morrow, J.A.,Pantling, J.,Rankovic, Z.,Smith, L. (deposition date: 2010-11-18, release date: 2011-01-12, Last modification date: 2017-08-09)
Primary citation	Jamieson, C.,Maclean, J.K.,Brown, C.I.,Campbell, R.A.,Gillen, K.J.,Gillespie, J.,Kazemier, B.,Kiczun, M.,Lamont, Y.,Lyons, A.J.,Moir, E.M.,Morrow, J.A.,Pantling, J.,Rankovic, Z.,Smith, L. Structure based evolution of a novel series of positive modulators of the AMPA receptor. Bioorg.Med.Chem.Lett., 21:805-811, 2011 Cited by PubMed Abstract: Starting from compound 1, we utilized biostructural data to successfully evolve an existing series into a new chemotype with a promising overall profile, exemplified by 19. PubMed: 21190850 DOI: 10.1016/j.bmcl.2010.11.098 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.87 Å)

Structure validation