3O2A

Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator

Summary for 3O2A

Entry DOI	10.2210/pdb3o2a/pdb
Related	3O28 3O29 3O6G 3O6H 3O6I 3PMV 3PMW 3PMX
Descriptor	Glutamate receptor 2, N-(3-aminopropyl)-2-({[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]acetyl}amino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, GLUTAMIC ACID, ... (6 entities in total)
Functional Keywords	transport protein, membrane protein, fusion protein, chimera protein
Biological source	Rattus norvegicus (rat) More
Cellular location	Cell membrane; Multi-pass membrane protein: P19491
Total number of polymer chains	1
Total formula weight	30184.66
Authors	Maclean, J.K.F.,Basten, S.,Campbell, R.A.,Cumming, I.A.,Gillen, K.J.,Gillespie, J.,Jamieson, C.,Kazemier, B.,Kiczun, M.,Lamont, Y.,Lyons, A.J.,Moir, E.M.,Morrow, J.A.,Papakosta, M.,Rankovic, Z.,Smith, L. (deposition date: 2010-07-22, release date: 2010-09-15, Last modification date: 2017-08-09)
Primary citation	Jamieson, C.,Basten, S.,Campbell, R.A.,Cumming, I.A.,Gillen, K.J.,Gillespie, J.,Kazemier, B.,Kiczun, M.,Lamont, Y.,Lyons, A.J.,Maclean, J.K.,Moir, E.M.,Morrow, J.A.,Papakosta, M.,Rankovic, Z.,Smith, L. A novel series of positive modulators of the AMPA receptor: discovery and structure based hit-to-lead studies. Bioorg.Med.Chem.Lett., 20:5753-5756, 2010 Cited by PubMed: 20805031 DOI: 10.1016/j.bmcl.2010.07.138 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation