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3O6I

Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator

Summary for 3O6I
Entry DOI10.2210/pdb3o6i/pdb
Related3O28 3O29 3O2A 3O6G 3O6H 3PMV 3PMW 3PMX
DescriptorGlutamate receptor 2, GLUTAMIC ACID, 2-[({3-tert-butyl-4-[(methylamino)methyl]-1H-pyrazol-1-yl}acetyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, ... (5 entities in total)
Functional Keywordstransport protein, membrane protein, fusion protein, chimera protein
Biological sourceRattus norvegicus (rat)
More
Cellular locationCell membrane; Multi-pass membrane protein: P19491
Total number of polymer chains1
Total formula weight30208.66
Authors
Primary citationJamieson, C.,Campbell, R.A.,Cumming, I.A.,Gillen, K.J.,Gillespie, J.,Kazemier, B.,Kiczun, M.,Lamont, Y.,Lyons, A.J.,Maclean, J.K.,Martin, F.,Moir, E.M.,Morrow, J.A.,Pantling, J.,Rankovic, Z.,Smith, L.
A novel series of positive modulators of the AMPA receptor: structure-based lead optimization.
Bioorg.Med.Chem.Lett., 20:6072-6075, 2010
Cited by
PubMed: 20817521
DOI: 10.1016/j.bmcl.2010.08.063
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

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