3O6I

Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GLU A 264

Chain	Residue
A	TYR61
A	TYR220
A	HOH370
A	HOH372
A	HOH396
A	PRO89
A	LEU90
A	THR91
A	ARG96
A	GLY141
A	SER142
A	THR143
A	GLU193

---

site_id	AC2
Number of Residues	17
Details	BINDING SITE FOR RESIDUE O26 A 265

Chain	Residue
A	ILE92
A	PRO105
A	PRO105
A	PHE106
A	MET107
A	SER108
A	SER108
A	SER217
A	LYS218
A	LYS218
A	GLY219
A	GLY219
A	LEU239
A	SER242
A	LEU247
A	SO4270
A	SO4270

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 266

Chain	Residue
A	GLY28
A	ASN29
A	GLU30
A	ARG149
A	LYS151
A	HOH308

---

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 267

Chain	Residue
A	ASP139
A	SER140
A	LYS144
A	ARG148
A	HOH373
A	HOH374
A	HOH375
A	HOH462

---

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 268

Chain	Residue
A	MET19
A	HIS23
A	GLU24
A	ARG31
A	LYS240
A	SO4269
A	HOH419
A	HOH420

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 269

Chain	Residue
A	GLU24
A	ARG31
A	HIS46
A	LYS240
A	GLN244
A	SO4268
A	HOH418

---

site_id	AC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 A 270

Chain	Residue
A	PHE106
A	MET107
A	SER108
A	SER217
A	O26265
A	O26265
A	HOH314
A	HOH350
A	HOH431
A	HOH432

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO

Chain	Residue	Details
A	PRO89
A	THR91
A	ARG96
A	SER142
A	THR143
A	GLU193

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ARG64
A	ARG148
A	LYS240

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ILE121

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER150

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER184

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN3

---