3PMX

Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GLU A 264

Chain	Residue
A	TYR61
A	TYR220
A	HOH409
A	HOH419
A	HOH422
A	PRO89
A	LEU90
A	THR91
A	ARG96
A	GLY141
A	SER142
A	THR143
A	GLU193

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 265

Chain	Residue
A	MET19
A	HIS23
A	GLU24
A	ARG31
A	LYS240
A	SO4268
A	HOH575

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 266

Chain	Residue
A	SER140
A	LYS144
A	ARG148
A	HOH314
A	HOH406
A	HOH423
A	HOH576

---

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 267

Chain	Residue
A	GLU27
A	GLY28
A	ASN29
A	GLU30
A	ARG149
A	EDO275
A	HOH297
A	HOH300

---

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 268

Chain	Residue
A	GLU24
A	ARG31
A	HIS46
A	LYS240
A	GLN244
A	SO4265
A	HOH344

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 269

Chain	Residue
A	LYS50
A	ARG148
A	ARG149
A	TRP159
A	ARG163

---

site_id	AC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 270

Chain	Residue
A	SER108
A	LEU109
A	SER194
A	GLU198
A	ASN214
A	HOH331
A	HOH461
A	HOH582

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS A 271

Chain	Residue
A	SER108
A	SER217
A	HOH279
A	HOH457

---

site_id	AC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DMS A 272

Chain	Residue
A	LYS4
A	VAL7
A	GLY81
A	LYS82
A	ALA83
A	ASP84
A	HOH349

---

site_id	BC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO A 273

Chain	Residue
A	GLY62
A	THR93
A	VAL95
A	ARG96
A	GLU145
A	HOH380
A	HOH423
A	HOH586

---

site_id	BC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO A 274

Chain	Residue
A	PHE146
A	ASP216
A	LYS218
A	GLU243
A	HOH280
A	HOH302
A	HOH372
A	HOH397

---

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 275

Chain	Residue
A	ASN29
A	LYS50
A	TYR51
A	SO4267
A	HOH300
A	HOH366

---

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 276

Chain	Residue
A	ASN214
A	ASP216
A	SER217
A	ASP248
A	HOH394

---

site_id	BC5
Number of Residues	14
Details	BINDING SITE FOR RESIDUE 808 A 277

Chain	Residue
A	LYS218
A	LYS218
A	GLY219
A	GLY219
A	LEU239
A	LEU239
A	SER242
A	HOH307
A	ILE92
A	LYS104
A	PRO105
A	PRO105
A	MET107
A	SER108

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO

Chain	Residue	Details
A	PRO89
A	THR91
A	ARG96
A	SER142
A	THR143
A	GLU193

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ARG64
A	ARG148
A	LYS240

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ILE121

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER150

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER184

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN3

---