3O6G
Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator
Summary for 3O6G
Entry DOI | 10.2210/pdb3o6g/pdb |
Related | 3O28 3O29 3O2A 3O6H 3O6I 3PMV 3PMW 3PMX |
Descriptor | Glutamate receptor 2, GLUTAMIC ACID, SULFATE ION, ... (6 entities in total) |
Functional Keywords | transport protein, membrane protein, fusion protein, chimera protein |
Biological source | Rattus norvegicus (rat) More |
Cellular location | Cell membrane; Multi-pass membrane protein: P19491 |
Total number of polymer chains | 1 |
Total formula weight | 30356.82 |
Authors | Maclean, J.K.F.,Campbell, R.A.,Cumming, I.A.,Gillen, K.J.,Gillespie, J.,Jamieson, C.,Kazemier, B.,Kiczun, M.,Lamont, Y.,Lyons, A.J.,Martin, F.,Moir, E.M.,Morrow, J.A.,Pantling, J.,Rankovic, Z.,Smith, L. (deposition date: 2010-07-29, release date: 2010-09-15, Last modification date: 2017-08-09) |
Primary citation | Jamieson, C.,Campbell, R.A.,Cumming, I.A.,Gillen, K.J.,Gillespie, J.,Kazemier, B.,Kiczun, M.,Lamont, Y.,Lyons, A.J.,Maclean, J.K.,Martin, F.,Moir, E.M.,Morrow, J.A.,Pantling, J.,Rankovic, Z.,Smith, L. A novel series of positive modulators of the AMPA receptor: structure-based lead optimization. Bioorg.Med.Chem.Lett., 20:6072-6075, 2010 Cited by PubMed: 20817521DOI: 10.1016/j.bmcl.2010.08.063 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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