3RN8

Crystal Structure of iGluR2 Ligand Binding Domain and Symmetrical Carboxyl Containing Potentiator

Summary for 3RN8

Entry DOI	10.2210/pdb3rn8/pdb
Related	1FTJ 1FTK 1FTL 1LB9 1LBC 3RNN
Descriptor	Glutamate receptor 2, GLUTAMIC ACID, 3,3'-benzene-1,4-diylbis(4-cyano-5-ethylthiophene-2-carboxylic acid), ... (7 entities in total)
Functional Keywords	glutamate receptor potentiator complex, ligand gated ion channel, membrane, transport protein
Biological source	Homo sapiens (human) More
Cellular location	Cell membrane ; Multi-pass membrane protein : P42262
Total number of polymer chains	3
Total formula weight	94596.11
Authors	Timm, D.E. (deposition date: 2011-04-22, release date: 2011-05-25, Last modification date: 2017-08-23)
Primary citation	Timm, D.E.,Benveniste, M.,Weeks, A.M.,Nisenbaum, E.S.,Partin, K.M. Structural and functional analysis of two new positive allosteric modulators of GluA2 desensitization and deactivation. Mol.Pharmacol., 80:267-280, 2011 Cited by PubMed: 21543522 DOI: 10.1124/mol.110.070243 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation