3RN8
Crystal Structure of iGluR2 Ligand Binding Domain and Symmetrical Carboxyl Containing Potentiator
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| A | 0016020 | cellular_component | membrane |
| B | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| B | 0016020 | cellular_component | membrane |
| C | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| C | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE GLU A 280 |
| Chain | Residue |
| A | TYR61 |
| A | GLU193 |
| A | TYR220 |
| A | HOH282 |
| A | HOH292 |
| A | HOH303 |
| A | PRO89 |
| A | LEU90 |
| A | THR91 |
| A | ARG96 |
| A | LEU138 |
| A | GLY141 |
| A | SER142 |
| A | THR143 |
| site_id | AC2 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE RN8 A 281 |
| Chain | Residue |
| A | PRO105 |
| A | MET107 |
| A | SER108 |
| A | SER217 |
| A | LYS218 |
| A | ASN242 |
| A | HOH291 |
| A | HOH306 |
| A | HOH311 |
| A | HOH419 |
| A | HOH584 |
| A | HOH610 |
| C | PRO105 |
| C | MET107 |
| C | SER108 |
| C | SER217 |
| C | LYS218 |
| C | ASN242 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE GLU B 280 |
| Chain | Residue |
| B | TYR61 |
| B | PRO89 |
| B | LEU90 |
| B | THR91 |
| B | ARG96 |
| B | LEU138 |
| B | GLY141 |
| B | SER142 |
| B | THR143 |
| B | GLU193 |
| B | TYR220 |
| B | HOH288 |
| B | HOH310 |
| B | HOH315 |
| site_id | AC4 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE RN8 B 281 |
| Chain | Residue |
| B | ILE92 |
| B | PRO105 |
| B | PRO105 |
| B | PHE106 |
| B | MET107 |
| B | SER108 |
| B | SER108 |
| B | SER217 |
| B | SER217 |
| B | LYS218 |
| B | LYS218 |
| B | GLY219 |
| B | LEU239 |
| B | ASN242 |
| B | ASN242 |
| B | HOH299 |
| B | HOH299 |
| B | HOH316 |
| B | HOH316 |
| B | HOH407 |
| B | HOH407 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 282 |
| Chain | Residue |
| A | GLU42 |
| A | HIS46 |
| B | GLU166 |
| B | SO4286 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 283 |
| Chain | Residue |
| B | HIS23 |
| B | GLU30 |
| B | HOH732 |
| C | HIS23 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN B 284 |
| Chain | Residue |
| A | GLU166 |
| B | GLU42 |
| B | HIS46 |
| B | LEU241 |
| B | GLN244 |
| B | HOH516 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT B 285 |
| Chain | Residue |
| B | ARG180 |
| B | SER184 |
| B | LYS187 |
| B | HOH771 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 B 286 |
| Chain | Residue |
| A | GLU42 |
| A | HIS46 |
| B | ARG163 |
| B | ALA165 |
| B | GLU166 |
| B | SER168 |
| B | ZN282 |
| B | HOH520 |
| site_id | BC1 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE GLU C 280 |
| Chain | Residue |
| C | GLY141 |
| C | SER142 |
| C | THR143 |
| C | GLU193 |
| C | TYR220 |
| C | HOH284 |
| C | HOH287 |
| C | HOH385 |
| C | TYR61 |
| C | PRO89 |
| C | LEU90 |
| C | THR91 |
| C | ARG96 |
| C | LEU138 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 281 |
| Chain | Residue |
| A | HIS23 |
| C | ASP65 |
| C | HOH441 |
| C | HOH815 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ZN C 282 |
| Chain | Residue |
| C | GLU42 |
| C | HIS46 |
| C | LEU246 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT C 283 |
| Chain | Residue |
| C | ARG180 |
| C | SER184 |
| C | LYS187 |
| C | TYR188 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20614889","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2XHD","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20614889","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21531559","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2XHD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3R7X","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20614889","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21531559","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2XHD","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"UniProtKB","id":"P19491","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"Phosphoserine; by PKG","evidences":[{"source":"UniProtKB","id":"P19491","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
