3RN8

Crystal Structure of iGluR2 Ligand Binding Domain and Symmetrical Carboxyl Containing Potentiator

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE GLU A 280

Chain	Residue
A	TYR61
A	GLU193
A	TYR220
A	HOH282
A	HOH292
A	HOH303
A	PRO89
A	LEU90
A	THR91
A	ARG96
A	LEU138
A	GLY141
A	SER142
A	THR143

---

site_id	AC2
Number of Residues	18
Details	BINDING SITE FOR RESIDUE RN8 A 281

Chain	Residue
A	PRO105
A	MET107
A	SER108
A	SER217
A	LYS218
A	ASN242
A	HOH291
A	HOH306
A	HOH311
A	HOH419
A	HOH584
A	HOH610
C	PRO105
C	MET107
C	SER108
C	SER217
C	LYS218
C	ASN242

---

site_id	AC3
Number of Residues	14
Details	BINDING SITE FOR RESIDUE GLU B 280

Chain	Residue
B	TYR61
B	PRO89
B	LEU90
B	THR91
B	ARG96
B	LEU138
B	GLY141
B	SER142
B	THR143
B	GLU193
B	TYR220
B	HOH288
B	HOH310
B	HOH315

---

site_id	AC4
Number of Residues	21
Details	BINDING SITE FOR RESIDUE RN8 B 281

Chain	Residue
B	ILE92
B	PRO105
B	PRO105
B	PHE106
B	MET107
B	SER108
B	SER108
B	SER217
B	SER217
B	LYS218
B	LYS218
B	GLY219
B	LEU239
B	ASN242
B	ASN242
B	HOH299
B	HOH299
B	HOH316
B	HOH316
B	HOH407
B	HOH407

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 282

Chain	Residue
A	GLU42
A	HIS46
B	GLU166
B	SO4286

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 283

Chain	Residue
B	HIS23
B	GLU30
B	HOH732
C	HIS23

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN B 284

Chain	Residue
A	GLU166
B	GLU42
B	HIS46
B	LEU241
B	GLN244
B	HOH516

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT B 285

Chain	Residue
B	ARG180
B	SER184
B	LYS187
B	HOH771

---

site_id	AC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 B 286

Chain	Residue
A	GLU42
A	HIS46
B	ARG163
B	ALA165
B	GLU166
B	SER168
B	ZN282
B	HOH520

---

site_id	BC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE GLU C 280

Chain	Residue
C	GLY141
C	SER142
C	THR143
C	GLU193
C	TYR220
C	HOH284
C	HOH287
C	HOH385
C	TYR61
C	PRO89
C	LEU90
C	THR91
C	ARG96
C	LEU138

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 281

Chain	Residue
A	HIS23
C	ASP65
C	HOH441
C	HOH815

---

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN C 282

Chain	Residue
C	GLU42
C	HIS46
C	LEU246

---

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT C 283

Chain	Residue
C	ARG180
C	SER184
C	LYS187
C	TYR188

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	9
Details	BINDING: BINDING => ECO:0000269|PubMed:20614889, ECO:0000269|PubMed:21531559

Chain	Residue	Details
A	TYR61
A	ARG96
A	GLU193
B	TYR61
B	ARG96
B	GLU193
C	TYR61
C	ARG96
C	GLU193

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING:

Chain	Residue	Details
A	PRO89
A	SER142
B	PRO89
B	SER142
C	PRO89
C	SER142

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000250|UniProtKB:P19491

Chain	Residue	Details
A	SER150
B	SER150
C	SER150

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000250|UniProtKB:P19491

Chain	Residue	Details
A	SER184
B	SER184
C	SER184

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN3
B	ASN3
C	ASN3

---