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2WDT
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BU of 2wdt by Molmil
Crystal structure of Plasmodium falciparum UCHL3 in complex with the suicide inhibitor UbVME
Descriptor: CHLORIDE ION, UBIQUITIN, UBIQUITIN CARBOXYL-TERMINAL HYDROLASE L3
Authors:Weihofen, W.A, Artavanis-Tsakonas, K, Gaudet, R, Ploegh, H.L.
Deposit date:2009-03-26
Release date:2009-12-29
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Characterization and Structural Studies of the Plasmodium Falciparum Ubiquitin and Nedd8 Hydrolase Uchl3.
J.Biol.Chem., 285, 2010
2XBB
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BU of 2xbb by Molmil
Nedd4 HECT:Ub complex
Descriptor: E3 UBIQUITIN-PROTEIN LIGASE NEDD4, GLYCEROL, UBIQUITIN
Authors:Maspero, E, Cecatiello, V, Musacchio, A, Polo, S, Pasqualato, S.
Deposit date:2010-04-08
Release date:2011-03-23
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Structure of the Hect:Ubiquitin Complex and its Role in Ubiquitin Chain Elongation
Embo Rep., 12, 2011
4PYU
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BU of 4pyu by Molmil
The conserved ubiquitin-like protein hub1 plays a critical role in splicing in human cells
Descriptor: U4/U6.U5 tri-snRNP-associated protein 1, Ubiquitin-like protein 5
Authors:Ammon, T, Mishra, S.K, Kowalska, K, Popowicz, G.M, Holak, T.A, Jentsch, S.
Deposit date:2014-03-28
Release date:2014-07-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:The conserved ubiquitin-like protein Hub1 plays a critical role in splicing in human cells.
J Mol Cell Biol, 6, 2014
2Y5B
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BU of 2y5b by Molmil
Structure of USP21 in complex with linear diubiquitin-aldehyde
Descriptor: SULFATE ION, UBIQUITIN, UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21, ...
Authors:Ye, Y, Akutsu, M, Reyes-Turcu, F, Enchev, R.I, Wilkinson, K.D, Komander, D.
Deposit date:2011-01-12
Release date:2012-01-25
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Polyubiquitin Binding and Cross-Reactivity in the Usp Domain Deubiquitinase Usp21.
Embo Rep., 12, 2011
4WLR
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BU of 4wlr by Molmil
Crystal Structure of mUCH37-hRPN13 CTD-hUb complex
Descriptor: Polyubiquitin-B, Proteasomal ubiquitin receptor ADRM1, Ubiquitin carboxyl-terminal hydrolase isozyme L5
Authors:Hemmis, C.W, Hill, C.P, VanderLinden, R, Whitby, F.G.
Deposit date:2014-10-07
Release date:2015-03-04
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.997 Å)
Cite:Structural Basis for the Activation and Inhibition of the UCH37 Deubiquitylase.
Mol.Cell, 57, 2015
4WQO
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BU of 4wqo by Molmil
Structure of VHL-EloB-EloC-Cul2
Descriptor: Cullin-2, Transcription elongation factor B polypeptide 1, Transcription elongation factor B polypeptide 2, ...
Authors:Nguyen, H.C, Xiong, Y.
Deposit date:2014-10-22
Release date:2015-03-04
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Insights into Cullin-RING E3 Ubiquitin Ligase Recruitment: Structure of the VHL-EloBC-Cul2 Complex.
Structure, 23, 2015
4WUR
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BU of 4wur by Molmil
The crystal structure of the MERS-CoV papain-like protease (C111S) with human ubiquitin
Descriptor: ISOPROPYL ALCOHOL, Papain-like protease, Polyubiquitin-B, ...
Authors:Lei, J, Hilgenfeld, R.
Deposit date:2014-11-03
Release date:2014-11-26
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.16 Å)
Cite:Structural and mutational analysis of the interaction between the Middle-East respiratory syndrome coronavirus (MERS-CoV) papain-like protease and human ubiquitin.
Virol Sin, 31, 2016
7JTP
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BU of 7jtp by Molmil
Crystal structure of Protac MS67 in complex with the WD repeat-containing protein 5 and pVHL:ElonginC:ElonginB
Descriptor: Elongin-B, Elongin-C, GLYCEROL, ...
Authors:Kottur, J, Jain, R, Aggarwal, A.K.
Deposit date:2020-08-18
Release date:2021-10-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models.
Sci Transl Med, 13, 2021
7JTO
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BU of 7jto by Molmil
Crystal structure of Protac MS33 in complex with the WD repeat-containing protein 5 and pVHL:ElonginC:ElonginB
Descriptor: 1,2-ETHANEDIOL, 3-methyl-N-(11-{[2-(4-{[4'-(4-methylpiperazin-1-yl)-3'-{[6-oxo-4-(trifluoromethyl)-5,6-dihydropyridine-3-carbonyl]amino}[1,1'-biphenyl]-3-yl]methyl}piperazin-1-yl)ethyl]amino}-11-oxoundecanoyl)-L-valyl-(4R)-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}-L-prolinamide, Elongin-B, ...
Authors:Kottur, J, Jain, R, Aggarwal, A.K.
Deposit date:2020-08-18
Release date:2021-10-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models.
Sci Transl Med, 13, 2021
7KHH
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BU of 7khh by Molmil
Ternary complex of VHL/BRD4-BD1/Compound9 (4-(3,5-difluoropyridin-2-yl)-N-(11-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-11-oxoundecyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulene-6-carboxamide)
Descriptor: Bromodomain-containing protein 4, Elongin-B, Elongin-C, ...
Authors:Murray, J.M.
Deposit date:2020-10-21
Release date:2021-02-24
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.281 Å)
Cite:Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy.
J.Med.Chem., 64, 2021
7JMS
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BU of 7jms by Molmil
Structure of the Hazara virus OTU bound to ubiquitin
Descriptor: CALCIUM ION, GLYCEROL, Polyubiquitin-B, ...
Authors:Dzimianski, J.V, Pegan, S.D.
Deposit date:2020-08-02
Release date:2020-10-21
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:Flipping the substrate preference of Hazara virus ovarian tumour domain protease through structure-based mutagenesis.
Acta Crystallogr D Struct Biol, 76, 2020
7JXV
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BU of 7jxv by Molmil
ANTH domain of CALM (clathrin-assembly lymphoid myeloid leukemia protein) bound to ubiquitin
Descriptor: Phosphatidylinositol-binding clathrin assembly protein, Ubiquitin
Authors:Pashkova, N, Gakhar, L, Schnicker, N.J, Piper, R.C.
Deposit date:2020-08-28
Release date:2021-08-04
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:ANTH domains within CALM, HIP1R, and Sla2 recognize ubiquitin internalization signals.
Elife, 10, 2021
7LTO
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BU of 7lto by Molmil
Nse5-6 complex
Descriptor: Non-structural maintenance of chromosome element 5, Ubiquitin-like protein SMT3,DNA repair protein KRE29 chimera
Authors:Yu, Y, Li, S.B, Zheng, S, Tangy, S, Koyi, C, Wan, B.B, Kung, H.H, Andrej, S, Alex, K, Patel, D.J, Zhao, X.L.
Deposit date:2021-02-19
Release date:2021-05-19
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Integrative analysis reveals unique structural and functional features of the Smc5/6 complex.
Proc.Natl.Acad.Sci.USA, 118, 2021
3CMM
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BU of 3cmm by Molmil
Crystal Structure of the Uba1-Ubiquitin Complex
Descriptor: PROLINE, Ubiquitin, Ubiquitin-activating enzyme E1 1
Authors:Lee, I, Schindelin, H.
Deposit date:2008-03-23
Release date:2008-08-05
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural insights into E1-catalyzed ubiquitin activation and transfer to conjugating enzymes.
Cell(Cambridge,Mass.), 134, 2008
3DCG
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BU of 3dcg by Molmil
Crystal Structure of the HIV Vif BC-box in Complex with Human ElonginB and ElonginC
Descriptor: Transcription elongation factor B polypeptide 1, Transcription elongation factor B polypeptide 2, Virion infectivity factor
Authors:Stanley, B.J, Ehrlich, E.S, Short, L, Yu, Y, Xiao, Z, Yu, X.-F, Xiong, Y.
Deposit date:2008-06-03
Release date:2008-07-08
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural insight into the human immunodeficiency virus Vif SOCS box and its role in human E3 ubiquitin ligase assembly
J.Virol., 82, 2008
3DVG
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BU of 3dvg by Molmil
Crystal structure of K63-specific fab Apu.3A8 bound to K63-linked di-ubiquitin
Descriptor: Human IgG1 fab fragment heavy chain, Human IgG1 fab fragment light chain, Ubiquitin, ...
Authors:Hymowitz, S.G.
Deposit date:2008-07-18
Release date:2008-09-30
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies.
Cell(Cambridge,Mass.), 134, 2008
3DQV
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BU of 3dqv by Molmil
Structural Insights into NEDD8 Activation of Cullin-RING Ligases: Conformational Control of Conjugation
Descriptor: Cullin-5, NEDD8, Rbx1, ...
Authors:Duda, D.M, Borg, L.A, Scott, D.C, Hunt, H.W, Hammel, M, Schulman, B.A.
Deposit date:2008-07-09
Release date:2008-09-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation.
Cell(Cambridge,Mass.), 134, 2008
3DVN
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BU of 3dvn by Molmil
Crystal structure of K63-specific fab Apu2.16 bound to K63-linked di-ubiquitin
Descriptor: Human IgG1 fab fragment heavy chain, Human IgG1 fab fragment light chain, Ubiquitin, ...
Authors:Hymowitz, S.G.
Deposit date:2008-07-18
Release date:2008-09-30
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies.
Cell(Cambridge,Mass.), 134, 2008
3DBH
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BU of 3dbh by Molmil
Structural Dissection of a Gating Mechanism Preventing Misactivation of Ubiquitin by NEDD8's E1 (APPBP1-UBA3Arg190Ala-NEDD8Ala72Arg)
Descriptor: NEDD8, NEDD8-activating enzyme E1 catalytic subunit, NEDD8-activating enzyme E1 regulatory subunit, ...
Authors:Souphron, J, Schulman, B.A.
Deposit date:2008-05-31
Release date:2008-08-12
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structural dissection of a gating mechanism preventing misactivation of ubiquitin by NEDD8's E1.
Biochemistry, 47, 2008
3DBL
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BU of 3dbl by Molmil
Structural Dissection of a Gating Mechanism Preventing Misactivation of Ubiquitin by NEDD8's E1 (APPBP1-UBA3Arg190wt-NEDD8Ala72Gln)
Descriptor: NEDD8, NEDD8-activating enzyme E1 catalytic subunit, NEDD8-activating enzyme E1 regulatory subunit, ...
Authors:Souphron, J, Schulman, B.A.
Deposit date:2008-06-01
Release date:2008-08-12
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural dissection of a gating mechanism preventing misactivation of ubiquitin by NEDD8's E1.
Biochemistry, 47, 2008
3DBR
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BU of 3dbr by Molmil
Structural Dissection of a Gating Mechanism Preventing Misactivation of Ubiquitin by NEDD8's E1 (APPBP1-UBA3Arg190Gln-NEDD8Ala72Arg)
Descriptor: NEDD8, NEDD8-activating enzyme E1 catalytic subunit, NEDD8-activating enzyme E1 regulatory subunit, ...
Authors:Souphron, J, Schulman, B.A.
Deposit date:2008-06-02
Release date:2008-08-12
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Structural dissection of a gating mechanism preventing misactivation of ubiquitin by NEDD8's E1.
Biochemistry, 47, 2008
3GZN
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BU of 3gzn by Molmil
Structure of NEDD8-activating enzyme in complex with NEDD8 and MLN4924
Descriptor: NEDD8, NEDD8-activating enzyme E1 catalytic subunit, NEDD8-activating enzyme E1 regulatory subunit, ...
Authors:Sintchak, M.D.
Deposit date:2009-04-07
Release date:2010-02-02
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3 Å)
Cite:Substrate-assisted inhibition of ubiquitin-like protein-activating enzymes: the NEDD8 E1 inhibitor MLN4924 forms a NEDD8-AMP mimetic in situ.
Mol.Cell, 37, 2010
7CJB
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BU of 7cjb by Molmil
VHL recognizes hydroxyproline in RIPK1
Descriptor: Elongin-B, Elongin-C, GLYCEROL, ...
Authors:Liu, J, Wang, Y, Pan, L.
Deposit date:2020-07-09
Release date:2021-07-14
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:VHL recognizes hydroxyproline in RIPK1
To Be Published
7DNJ
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BU of 7dnj by Molmil
K63-polyUb MDA5CARDs complex
Descriptor: Interferon-induced helicase C domain-containing protein 1, Ubiquitin
Authors:Song, B, Chen, Y, Luo, D.H, Zheng, J.
Deposit date:2020-12-09
Release date:2021-10-13
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Ordered assembly of the cytosolic RNA-sensing MDA5-MAVS signaling complex via binding to unanchored K63-linked poly-ubiquitin chains.
Immunity, 54, 2021
7DNI
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BU of 7dni by Molmil
MDA5 CARDs-MAVS CARD polyUb complex
Descriptor: Interferon-induced helicase C domain-containing protein 1, Mitochondrial antiviral-signaling protein, Ubiquitin
Authors:Song, B, Chen, Y, Luo, D.H, Zheng, J.
Deposit date:2020-12-09
Release date:2021-10-13
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Ordered assembly of the cytosolic RNA-sensing MDA5-MAVS signaling complex via binding to unanchored K63-linked poly-ubiquitin chains.
Immunity, 54, 2021

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数据于2024-07-10公开中

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