7JTO

Crystal structure of Protac MS33 in complex with the WD repeat-containing protein 5 and pVHL:ElonginC:ElonginB

Summary for 7JTO

Entry DOI	10.2210/pdb7jto/pdb
Descriptor	WD repeat-containing protein 5, Elongin-B, Elongin-C, ... (10 entities in total)
Functional Keywords	protac, protein degradation, ubiquitination, protein binding
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	77329.19
Authors	Kottur, J.,Jain, R.,Aggarwal, A.K. (deposition date: 2020-08-18, release date: 2021-10-06, Last modification date: 2023-10-18)
Primary citation	Yu, X.,Li, D.,Kottur, J.,Shen, Y.,Kim, H.S.,Park, K.S.,Tsai, Y.H.,Gong, W.,Wang, J.,Suzuki, K.,Parker, J.,Herring, L.,Kaniskan, H.U.,Cai, L.,Jain, R.,Liu, J.,Aggarwal, A.K.,Wang, G.G.,Jin, J. A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models. Sci Transl Med, 13:eabj1578-eabj1578, 2021 Cited by PubMed: 34586829 DOI: 10.1126/scitranslmed.abj1578 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation