7JTO
Crystal structure of Protac MS33 in complex with the WD repeat-containing protein 5 and pVHL:ElonginC:ElonginB
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | WD repeat-containing protein 5 | polymer | 308 | 34037.6 | 1 | UniProt (P61964) Pfam (PF00400) | Homo sapiens (Human) | BMP2-induced 3-kb gene protein |
| 2 | B (J) | Elongin-B | polymer | 104 | 11748.4 | 1 | UniProt (Q15370) Pfam (PF00240) | Homo sapiens (Human) | EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2 |
| 3 | C (K) | Elongin-C | polymer | 97 | 10974.6 | 1 | UniProt (Q15369) Pfam (PF03931) | Homo sapiens (Human) | EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1 |
| 4 | D (L) | von Hippel-Lindau disease tumor suppressor | polymer | 162 | 18702.3 | 1 | UniProt (P40337) Pfam (PF01847) Pfam (PF17211) | Homo sapiens (Human) | Protein G7,pVHL |
| 5 | E, F, H, K (B, J) | THIOCYANATE ION | non-polymer | 58.1 | 4 | Chemie (SCN) | |||
| 6 | G, I, M, N, O (B, K, L) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 7 | J (B) | 3-methyl-N-(11-{[2-(4-{[4'-(4-methylpiperazin-1-yl)-3'-{[6-oxo-4-(trifluoromethyl)-5,6-dihydropyridine-3-carbonyl]amino}[1,1'-biphenyl]-3-yl]methyl}piperazin-1-yl)ethyl]amino}-11-oxoundecanoyl)-L-valyl-(4R)-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}-L-prolinamide | non-polymer | 1208.5 | 1 | Chemie (VKA) | |||
| 8 | L (K) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 9 | P (L) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 10 | Q, R, S, T (B, J, K, L) | water | water | 18.0 | 624 | Chemie (HOH) |
Sequence modifications
B: 31 - 334 (UniProt: P61964)
K: 17 - 112 (UniProt: Q15369)
L: 54 - 213 (UniProt: P40337)
| PDB | External Database | Details |
|---|---|---|
| Glu 27 | - | expression tag |
| Phe 28 | - | expression tag |
| His 29 | - | expression tag |
| Met 30 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 16 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Gly 52 | - | expression tag |
| Ser 53 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 75463.0 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 1866.2 | |
| All* | Total formula weight | 77329.2 |
