Structural Insights into NEDD8 Activation of Cullin-RING Ligases: Conformational Control of Conjugation

Summary for 3DQV

DescriptorNEDD8, Cullin-5, Rbx1, ... (4 entities in total)
Functional Keywordsubiquitin, nedd8, scf, cullin-ring ligase, cullin, nucleus, ubl conjugation pathway, host-virus interaction, receptor, ubl conjugation, acetylation, cytoplasm, dna damage, dna repair, metal-binding, zinc, zinc-finger, signaling protein, ligase
Biological sourceHomo sapiens (human)
Cellular locationNucleus Q15843
Cytoplasm P62877
Total number of polymer chains6
Total molecular weight134119.07
Duda, D.M.,Borg, L.A.,Scott, D.C.,Hunt, H.W.,Hammel, M.,Schulman, B.A. (deposition date: 2008-07-09, release date: 2008-09-30, Last modification date: 2011-07-13)
Primary citation
Duda, D.M.,Borg, L.A.,Scott, D.C.,Hunt, H.W.,Hammel, M.,Schulman, B.A.
Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation.
Cell(Cambridge,Mass.), 134:995-1006, 2008
PubMed: 18805092 (PDB entries with the same primary citation)
DOI: 10.1016/j.cell.2008.07.022
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.23536 4.6% 6.4% 3.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-11-25